ExoticRx · exoticrx.com/drugs/diazoxide
US brand names:Proglycem
Diazoxide is dosed at 5–30 mg/kg PO q12h in dogs, per Nelson RW. Chapter 9: Beta-Cell Neoplasia: Insulinoma. In: Feldman EC, Nelson RW, Reusch CE, Scott-Moncrieff JCR, Behrend EN, eds. Canine and Feline Endocrinology. 4th ed. Elsevier Saunders; 2015:348-375. doi:10.1016/b978-1-4557-4456-5.00009-2 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.410 (2026-08-01).. Verify against current literature before clinical use.
Opens KATP channels in pancreatic beta cells, inhibiting insulin secretion. Also has extrapancreatic hyperglycemic effects.
Used for insulinoma management (dogs). GI upset, anorexia, hypotension. Sodium and fluid retention (may need diuretic). Monitor blood glucose. Expensive.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 5–30 mg/kg | q12h | Moderate | Nelson RW. Chapter 9: Beta-Cell Neoplasia: Insulinoma. In: Feldman EC, Nelson RW, Reusch CE, Scott-Moncrieff JCR, Behrend EN, eds. Canine and Feline Endocrinology. 4th ed. Elsevier Saunders; 2015:348-375. doi:10.1016/b978-1-4557-4456-5.00009-2 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.410 (2026-08-01). |
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