Pocket Pet · Oryctolagus cuniculus · typical adult weight 1.00–5.00 kg
Atipamezole is dosed at If a higher dose of dexmedetomidine was administered, increase this dose accordingly." Published figures, rabbit — SOURCES DIFFER: Plumb's 10th ed printed p.107 gives 0.5 mg/kg IM or SC, 0.25 mg/kg IV, alternatively 0.75 mg/kg IV or IM; Carpenter's Exotic Animal Formulary 6th ed, Table 10.22, gives 1 mg/kg SC, IM, IV in rabbits, per Morissey JM, Carpenter JW. Appendix: Formulary. In: Quesenberry KE, Orcutt CJ, Mans C, et al. Ferrets, Rabbits and Rodents: Clinical Medicine and Surgery, 4th ed., Elsevier, St. Louis, MO; 2021:620-630. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.855 (2026-08-01). — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929; Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery — ISBN 9780323484350, https://openlibrary.org/isbn/9780323484350. Atipamezole is used in rabbits for Medetomidine/dexmedetomidine reversal. Routes documented in rabbits: IM. A typical adult rabbit weighs 1.00–5.00 kg. ExoticRx lists 1 cited dose rule for Atipamezole in rabbits, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Antisedan
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IM |
| If a higher dose of dexmedetomidine was administered, increase this dose accordingly." Published figures, rabbit — SOURCES DIFFER: Plumb's 10th ed printed p.107 gives 0.5 mg/kg IM or SC, 0.25 mg/kg IV, alternatively 0.75 mg/kg IV or IM; Carpenter's Exotic Animal Formulary 6th ed, Table 10.22, gives 1 mg/kg SC, IM, IV |
| Equal volume to medetomidine given |
| Single dose |
| Medetomidine/dexmedetomidine reversal |
| Strong |
| Morissey JM, Carpenter JW. Appendix: Formulary. In: Quesenberry KE, Orcutt CJ, Mans C, et al. Ferrets, Rabbits and Rodents: Clinical Medicine and Surgery, 4th ed., Elsevier, St. Louis, MO; 2021:620-630. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.855 (2026-08-01). — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929; Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery — ISBN 9780323484350, https://openlibrary.org/isbn/9780323484350 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.25 | IV | Carpenter's Exotic Animal Formulary, 6th edTable 10.4 | Give same volume SC, De IV, IP as medetomidine or dexmedetomidine (5 × medetomidine or 10 × dexmedetomidine dose in mg)166 0.25 mg/kg IV |
| 0.5 | SC | Carpenter's Exotic Animal Formulary, 6th edTable 10.4 | 0.5 mg/kg SC, IM 1 mg/kg SC, IM, IV |
| 1 | SC | Carpenter's Exotic Animal Formulary, 6th edTable 10.4 | 0.5 mg/kg SC, IM 1 mg/kg SC, IM, IV |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Selective alpha-2 adrenergic antagonist. Specifically reverses sedation, bradycardia, and other effects of medetomidine/dexmedetomidine.
IM route only (IV can cause cardiovascular excitation). Give equal volume to medetomidine or 5x volume of dexmedetomidine. Reversal within 5-10 minutes. May unmask pain.
Species-specific contraindications and adverse-reaction reports for rabbits may differ from canine / feline reference data — consult the primary citations listed with each rule.
Atipamezole dose range in rabbits, with cited source references: IM If a higher dose of dexmedetomidine was administered, increase this dose accordingly." Published figures, rabbit — SOURCES DIFFER: Plumb's 10th ed printed p.107 gives 0.5 mg/kg IM or SC, 0.25 mg/kg IV, alternatively 0.75 mg/kg IV or IM; Carpenter's Exotic Animal Formulary 6th ed, Table 10.22, gives 1 mg/kg SC, IM, IV Equal volume to medetomidine given. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Atipamezole in rabbits: IM.
Cited course lengths for Atipamezole in rabbits include: Single dose. Duration depends on the indication — match it to the specific dose rule in the table above.
Atipamezole is indicated in rabbits for: Medetomidine/dexmedetomidine reversal.
These are general warnings for Atipamezole across species; consult the rabbit dosing table above for species-specific guidance. IM route only (IV can cause cardiovascular excitation). Give equal volume to medetomidine or 5x volume of dexmedetomidine. Reversal within 5-10 minutes. May unmask pain.
Why a species-specific page? Atipamezole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in rabbits — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.