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Atipamezole for Rabbit

Pocket Pet · Oryctolagus cuniculus · typical adult weight 1.00–5.00 kg

Atipamezole is used in rabbit for Medetomidine/dexmedetomidine reversal. Routes documented in rabbit: IM. A typical adult rabbit weighs 1.00–5.00 kg. ExoticRx lists 1 cited dose rule for Atipamezole in rabbit, drawn from published veterinary references. Verify against current literature before clinical use.

Trade names: Antisedan

Dose ranges

RouteDoseFrequencyDurationIndicationEvidenceSource
IM0 mg/kgEqual volume to medetomidine givenSingle doseMedetomidine/dexmedetomidine reversalStrongCarpenter's Exotic Animal Formulary, 6th Ed

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Mechanism of action

Selective alpha-2 adrenergic antagonist. Specifically reverses sedation, bradycardia, and other effects of medetomidine/dexmedetomidine.

Side effects & warnings

IM route only (IV can cause cardiovascular excitation). Give equal volume to medetomidine or 5x volume of dexmedetomidine. Reversal within 5-10 minutes. May unmask pain.

Species-specific contraindications and adverse-reaction reports for rabbit may differ from canine / feline reference data — consult the primary citations listed with each rule.

Other Antidote drugs with rabbit dosing

Atipamezole dosing in other species

Why a species-specific page? Atipamezole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in rabbit — the rules above are the citations specific to this species, not generic recommendations.

Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.