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Busulfan

Myleran, Busulfex

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Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Oncology

Routes

POIV

Indications

chronic myeloid leukemiaPolycythemia vera

Mechanism of Action

Bifunctional alkylating agent that cross-links DNA strands, interfering with DNA replication and transcription. Preferentially affects granulocyte precursors.

Side effects & warnings

Severe myelosuppression — monitor CBC closely. Pulmonary fibrosis with chronic use. Hepatotoxicity (sinusoidal obstruction syndrome). Limited veterinary use for polycythemia vera and CML.

Species with Busulfan dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs

Evidence levels across 2 dose rules

Moderate×1Weak×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published source

  • · Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO3–4 mg/kgPO q24h until target PCV, then maint.ModerateWithrow & MacEwen's Small Animal Clinical Oncology, 6th Ed
Cat (Domestic)PO2–4 mg/kgPO q24h until remissionWeakWithrow & MacEwen's Small Animal Clinical Oncology, 6th Ed

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