ExoticRx · exoticrx.com/drugs/carboplatin
US brand names:Paraplatin
Carboplatin is dosed at 10 mg/kg total (maximum) Intralesional q3wk in veiled chameleons, per Johnson JG, Naples LM, Chu C, et al. Cutaneous squamous cell carcinoma in a panther chameleon (Furcifer pardalis) and treatment with carboplatin implantable beads. J Zoo Wildl Med. 2016;47:931-934. — Source: Mader's Reptile and Amphibian Medicine and Surgery 3rd ed, Table 127.9, printed p.1209; also Carpenter's Exotic Animal Formulary 6th ed, Table 4.11. Verify against current literature before clinical use.
Platinum compound forming DNA intrastrand crosslinks and adducts inhibiting DNA replication and transcription. Cell-cycle non-specific.
Less nephrotoxic than cisplatin. Dose-limiting myelosuppression (thrombocytopenia nadir 14-21 days). FATAL IN CATS at standard dog doses. Monitor CBC.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugsAll Veiled Chameleon drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 300 mg/m2 | q21 days | Strong | Plumb's 10th ed printed p.186, Carboplatin monograph spanning p.186-188.Compilation only — we have not located an independent source that prints this figure. |
| Cat (Domestic) | IV | 180–240 mg/m2 | q21 days | Moderate | Kisseberth WC, Vail DM, Yaissle J, et al. Phase I clinical evaluation of carboplatin in tumor-bearing cats: a Veterinary Cooperative Oncology Group study. J Vet Intern Med. 2008;22:83-88. doi:10.1111/j.1939-1676.2007.0017.x — Plumb's 10th ed printed p.186, Carboplatin monograph spanning p.186-188. |
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