ExoticRx · exoticrx.com/drugs/cisplatin
Cisplatin
Platinol
Drug Class
Routes
Indications
Mechanism of Action
Forms DNA intrastrand and interstrand crosslinks leading to cell death. Most potent platinum agent.
Side effects & warnings
ABSOLUTELY CONTRAINDICATED IN CATS (fatal pulmonary edema). Aggressive saline diuresis required to prevent nephrotoxicity. Severe emesis — antiemetic protocol mandatory. Ototoxic.
Species with Cisplatin dosing data (1 dose rule)
Species references:All Dog (Domestic) drugs
Evidence levels across 1 dose rule
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Backed by a published source
- · Plumb's Veterinary Drug Handbook, 9th Ed
Sample dosing (1 of 1 cited rule)
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 60–70 mg/m2 | q21 days | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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Source citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.