Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Cisplatin is dosed at 60–70 mg/m2 IV q21 days in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Cisplatin is used in dogs for Osteosarcoma, carcinomas. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Cisplatin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Platinol
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 60–70 mg/m2 | q21 days | 4-6 cycles | Osteosarcoma, carcinomas | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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Forms DNA intrastrand and interstrand crosslinks leading to cell death. Most potent platinum agent.
ABSOLUTELY CONTRAINDICATED IN CATS (fatal pulmonary edema). Aggressive saline diuresis required to prevent nephrotoxicity. Severe emesis — antiemetic protocol mandatory. Ototoxic.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Cisplatin dose range in dogs, with cited source references: IV 60–70 mg/m2 q21 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Cisplatin in dogs: IV.
Cited course lengths for Cisplatin in dogs include: 4-6 cycles. Duration depends on the indication — match it to the specific dose rule in the table above.
Cisplatin is indicated in dogs for: Osteosarcoma, carcinomas.
These are general warnings for Cisplatin across species; consult the dog dosing table above for species-specific guidance. ABSOLUTELY CONTRAINDICATED IN CATS (fatal pulmonary edema). Aggressive saline diuresis required to prevent nephrotoxicity. Severe emesis — antiemetic protocol mandatory. Ototoxic.
Why a species-specific page? Cisplatin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.