Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Cisplatin is dosed at 60–70 mg/m2 IV q21 days in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.271, Cisplatin monograph spanning p.271-273; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Cisplatin is used in dogs for Osteosarcoma, carcinomas. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Cisplatin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Platinol
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 60–70 mg/m2 | q21 days | 4-6 cycles | Osteosarcoma, carcinomas | Strong | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.271, Cisplatin monograph spanning p.271-273; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/m2) | Route | Source | As printed |
|---|---|---|---|
| 60–70 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.192 | • 60-70 mg/m2 q3-4wks IV (administer fluid for diuresis with therapy). |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Forms DNA intrastrand and interstrand crosslinks leading to cell death. Most potent platinum agent.
ABSOLUTELY CONTRAINDICATED IN CATS (fatal pulmonary edema). Aggressive saline diuresis required to prevent nephrotoxicity. Severe emesis — antiemetic protocol mandatory. Ototoxic.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Cisplatin dose range in dogs, with cited source references: IV 60–70 mg/m2 q21 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Cisplatin in dogs: IV.
Cited course lengths for Cisplatin in dogs include: 4-6 cycles. Duration depends on the indication — match it to the specific dose rule in the table above.
Cisplatin is indicated in dogs for: Osteosarcoma, carcinomas.
These are general warnings for Cisplatin across species; consult the dog dosing table above for species-specific guidance. ABSOLUTELY CONTRAINDICATED IN CATS (fatal pulmonary edema). Aggressive saline diuresis required to prevent nephrotoxicity. Severe emesis — antiemetic protocol mandatory. Ototoxic.
Why a species-specific page? Cisplatin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.