Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Fluorouracil is used in dog for Carcinomas / adenocarcinomas, Superficial squamous cell carcinoma / actinic keratosis. Routes documented in dog: IV, Topical. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Fluorouracil in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Efudex, 5-FU
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 150 mg/kg | 150mg/m2 IV weekly | Monitor CBC nadir at day 7-10 | Carcinomas / adenocarcinomas | Moderate | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
| Topical | 0 mg/kg | Apply 5% cream to lesion q12h | 2-4 weeks; E-collar mandatory to prevent ingestion | Superficial squamous cell carcinoma / actinic keratosis | Moderate | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Converted to active metabolites that inhibit thymidylate synthase, blocking DNA synthesis. Also incorporates into RNA, disrupting RNA processing.
LETHAL TO CATS — even topical exposure can be fatal. Severe neurotoxicity in cats. In dogs, causes myelosuppression and GI toxicity. Handle with extreme caution.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Fluorouracil pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.