Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Fluorouracil is used in dogs for Superficial squamous cell carcinoma / actinic keratosis. Routes documented in dogs: Topical. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Fluorouracil in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Efudex, 5-FU
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| Topical | Topical only for superficial skin tumors | Apply 5% cream to lesion q12h | 2-4 weeks; E-collar mandatory to prevent ingestion | Superficial squamous cell carcinoma / actinic keratosis | Moderate | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Converted to active metabolites that inhibit thymidylate synthase, blocking DNA synthesis. Also incorporates into RNA, disrupting RNA processing.
LETHAL TO CATS — even topical exposure can be fatal. Severe neurotoxicity in cats. In dogs, causes myelosuppression and GI toxicity. Handle with extreme caution.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Fluorouracil dose range in dogs, with cited source references: Topical Topical only for superficial skin tumors Apply 5% cream to lesion q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Fluorouracil in dogs: Topical.
Cited course lengths for Fluorouracil in dogs include: 2-4 weeks; E-collar mandatory to prevent ingestion. Duration depends on the indication — match it to the specific dose rule in the table above.
Fluorouracil is indicated in dogs for: Superficial squamous cell carcinoma / actinic keratosis.
These are general warnings for Fluorouracil across species; consult the dog dosing table above for species-specific guidance. LETHAL TO CATS — even topical exposure can be fatal. Severe neurotoxicity in cats. In dogs, causes myelosuppression and GI toxicity. Handle with extreme caution.
Why a species-specific page? Fluorouracil pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.