ExoticRx · exoticrx.com/drugs/fluorouracil
Efudex, 5-FU
Converted to active metabolites that inhibit thymidylate synthase, blocking DNA synthesis. Also incorporates into RNA, disrupting RNA processing.
LETHAL TO CATS — even topical exposure can be fatal. Severe neurotoxicity in cats. In dogs, causes myelosuppression and GI toxicity. Handle with extreme caution.
Species references:All Dog (Domestic) drugs
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