ExoticRx · exoticrx.com/drugs/capecitabine
Capecitabine
Xeloda
Drug Class
Routes
Indications
Mechanism of Action
Oral prodrug of 5-fluorouracil. Converted to 5-FU preferentially in tumor tissue via thymidine phosphorylase, providing tumor-selective activation.
Side effects & warnings
CONTRAINDICATED IN CATS — metabolized to 5-FU which is lethal to felines. GI toxicity and hand-foot syndrome in humans. Very limited canine data. Handle with extreme caution around cats.
Species with Capecitabine dosing data (2 dose rules)
Species references:All Dog (Domestic) drugs
Evidence levels across 2 dose rules
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Backed by a published source
- · Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed
Sample dosing (2 of 2 cited rules)
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 200–300 mg/kg | 200-300mg/m2 PO q12h, 14 days on / 7 days off | Anecdotal | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
| Dog (Domestic) | PO | 200–250 mg/kg | 200-250mg/m2 PO q12h, 14 days on / 7 days off | Anecdotal | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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Source citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.