ExoticRx · exoticrx.com/drugs/chlorambucil
US brand names:Leukeran
Chlorambucil is dosed at 2 mg/kg PO 2×/wk in umbrella cockatoos, per 773. Rivera S, McClearen JR, Reavill DR. Treatment of nonepitheliotropic cutaneous B-cell lymphoma in an umbrella cockatoo (Cacatua alba). J Avian Med Surg. 2009;23:294-302. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.482 — Carpenter's Exotic Animal Formulary 6th ed, Table 5.13 (Oncologic Agents and Radiation Therapy Used in Birds). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Verify against current literature before clinical use.
Alkylates DNA, forming cross-links that inhibit DNA replication and transcription. Slow-acting with relatively mild myelosuppression.
Cytotoxic — handler precautions required (gloves). Myelosuppression (monitor CBC q2 weeks initially). Commonly used for feline small cell lymphoma and IBD. Well-tolerated in cats.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugsAll Umbrella Cockatoo drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 3 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | PO | 2 mg per cat | q48-72h | Strong | Kiselow MA, Rassnick KM, McDonough SP, et al. Outcome of cats with low-grade lymphocytic lymphoma: 41 cases (1995-2005). Javma-Journal of the American Veterinary Medical Association. 2008;232(3):405-410. doi:10.2460/javma.232.3.405 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.271 (2026-08-01). — Plumb's 10th ed (held) printed p.244, Chlorambucil monograph spanning p.243-244; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Dog (Domestic) | PO | 4–6 mg/m2 | q24-48h | Moderate |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.
| Horta RS, Lavalle GE, Costa MP, Moura LL, Marcinowska A, Araujo RB. Outcome of adjuvant chemotherapy with lomustine, vinblastine and chlorambucil on management of canine mast cell tumour of high to intermediate risk. Arquivo Brasileiro De Medicina Veterinaria E Zootecnia. 2017;69(6):1426-1436. / 23. Withrow S, Vail D, Page RL. Withrow and MacEwen's Small Animal Clinical Oncology, 5th Ed.: Saunders; 2012. doi:10.1590/1678-4162-9172 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.271 (2026-08-01). — Plumb's 10th ed (held) printed p.243, Chlorambucil monograph spanning p.243-244; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Withrow and MacEwen's Small Animal Clinical Oncology — ISBN 9781437723625, https://openlibrary.org/isbn/9781437723625 |