ExoticRx · exoticrx.com/drugs/chlorambucil
US brand names:Leukeran
Chlorambucil is dosed at 2 mg/kg PO 2×/wk in umbrella cockatoos, per 773. Rivera S, McClearen JR, Reavill DR. Treatment of nonepitheliotropic cutaneous B-cell lymphoma in an umbrella cockatoo (Cacatua alba). J Avian Med Surg. 2009;23:294-302. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.482 — Carpenter's Exotic Animal Formulary 6th ed, Table 5.13 (Oncologic Agents and Radiation Therapy Used in Birds). Verify against current literature before clinical use.
Alkylates DNA, forming cross-links that inhibit DNA replication and transcription. Slow-acting with relatively mild myelosuppression.
Cytotoxic — handler precautions required (gloves). Myelosuppression (monitor CBC q2 weeks initially). Commonly used for feline small cell lymphoma and IBD. Well-tolerated in cats.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugsAll Umbrella Cockatoo drugs
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A dog/cat sample is shown here. Cited dosing for all 3 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | PO | 2 mg per cat | q48-72h | Strong | Kiselow MA, Rassnick KM, McDonough SP, et al. Outcome of cats with low-grade lymphocytic lymphoma: 41 cases (1995-2005). Javma-Journal of the American Veterinary Medical Association. 2008;232(3):405-410. doi:10.2460/javma.232.3.405 — Plumb's 10th ed printed p.244, Chlorambucil monograph spanning p.243-244. |
| Dog (Domestic) | PO | 4–6 mg/m2 | q24-48h | Moderate | Horta RS, Lavalle GE, Costa MP, Moura LL, Marcinowska A, Araujo RB. Outcome of adjuvant chemotherapy with lomustine, vinblastine and chlorambucil on management of canine mast cell tumour of high to intermediate risk. Arquivo Brasileiro De Medicina Veterinaria E Zootecnia. 2017;69(6):1426-1436. / 23. Withrow S, Vail D, Page RL. Withrow and MacEwen's Small Animal Clinical Oncology, 5th Ed.: Saunders; 2012. — Plumb's 10th ed printed p.243, Chlorambucil monograph spanning p.243-244. |
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