Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Chlorambucil is dosed at 4–6 mg/m2 PO q24-48h in dogs, per Horta RS, Lavalle GE, Costa MP, Moura LL, Marcinowska A, Araujo RB. Outcome of adjuvant chemotherapy with lomustine, vinblastine and chlorambucil on management of canine mast cell tumour of high to intermediate risk. Arquivo Brasileiro De Medicina Veterinaria E Zootecnia. 2017;69(6):1426-1436. / 23. Withrow S, Vail D, Page RL. Withrow and MacEwen's Small Animal Clinical Oncology, 5th Ed.: Saunders; 2012. doi:10.1590/1678-4162-9172 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.271 (2026-08-01).. Chlorambucil is used in dogs for Lymphoma (COP protocol component), CLL. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Chlorambucil in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Leukeran
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 4–6 mg/m2 | q24-48h | Per protocol | Lymphoma (COP protocol component), CLL | Moderate | Horta RS, Lavalle GE, Costa MP, Moura LL, Marcinowska A, Araujo RB. Outcome of adjuvant chemotherapy with lomustine, vinblastine and chlorambucil on management of canine mast cell tumour of high to intermediate risk. Arquivo Brasileiro De Medicina Veterinaria E Zootecnia. 2017;69(6):1426-1436. / 23. Withrow S, Vail D, Page RL. Withrow and MacEwen's Small Animal Clinical Oncology, 5th Ed.: Saunders; 2012. doi:10.1590/1678-4162-9172 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.271 (2026-08-01). |
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Alkylates DNA, forming cross-links that inhibit DNA replication and transcription. Slow-acting with relatively mild myelosuppression.
Cytotoxic — handler precautions required (gloves). Myelosuppression (monitor CBC q2 weeks initially). Commonly used for feline small cell lymphoma and IBD. Well-tolerated in cats.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Chlorambucil dose range in dogs, with cited source references: PO 4–6 mg/m2 q24-48h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Chlorambucil in dogs: PO.
Cited course lengths for Chlorambucil in dogs include: Per protocol. Duration depends on the indication — match it to the specific dose rule in the table above.
Chlorambucil is indicated in dogs for: Lymphoma (COP protocol component), CLL.
These are general warnings for Chlorambucil across species; consult the dog dosing table above for species-specific guidance. Cytotoxic — handler precautions required (gloves). Myelosuppression (monitor CBC q2 weeks initially). Commonly used for feline small cell lymphoma and IBD. Well-tolerated in cats.
Why a species-specific page? Chlorambucil pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.