Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Chlorambucil is dosed at 4–6 mg/m2 PO q24-48h in dogs, per Horta RS, Lavalle GE, Costa MP, Moura LL, Marcinowska A, Araujo RB. Outcome of adjuvant chemotherapy with lomustine, vinblastine and chlorambucil on management of canine mast cell tumour of high to intermediate risk. Arquivo Brasileiro De Medicina Veterinaria E Zootecnia. 2017;69(6):1426-1436. / 23. Withrow S, Vail D, Page RL. Withrow and MacEwen's Small Animal Clinical Oncology, 5th Ed.: Saunders; 2012. doi:10.1590/1678-4162-9172 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.271 (2026-08-01). — Plumb's 10th ed (held) printed p.243, Chlorambucil monograph spanning p.243-244; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Withrow and MacEwen's Small Animal Clinical Oncology — ISBN 9781437723625, https://openlibrary.org/isbn/9781437723625. Chlorambucil is used in dogs for Lymphoma (COP protocol component), CLL. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Chlorambucil in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Leukeran
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 4–6 mg/m2 | q24-48h | Per protocol | Lymphoma (COP protocol component), CLL | Moderate | Horta RS, Lavalle GE, Costa MP, Moura LL, Marcinowska A, Araujo RB. Outcome of adjuvant chemotherapy with lomustine, vinblastine and chlorambucil on management of canine mast cell tumour of high to intermediate risk. Arquivo Brasileiro De Medicina Veterinaria E Zootecnia. 2017;69(6):1426-1436. / 23. Withrow S, Vail D, Page RL. Withrow and MacEwen's Small Animal Clinical Oncology, 5th Ed.: Saunders; 2012. doi:10.1590/1678-4162-9172 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.271 (2026-08-01). — Plumb's 10th ed (held) printed p.243, Chlorambucil monograph spanning p.243-244; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Withrow and MacEwen's Small Animal Clinical Oncology — ISBN 9781437723625, https://openlibrary.org/isbn/9781437723625 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.2 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.92 | ge/frequency as required to maintain remission; or 0.2 mg/kg q24h for 7 days then 0.1 mg/kg q24h for maintenance; or 20 mg/m2 every 1-2 weeks |
| 0.1 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.92 | ed to maintain remission; or 0.2 mg/kg q24h for 7 days then 0.1 mg/kg q24h for maintenance; or 20 mg/m2 every 1-2 weeks. Often used with prednisolone |
| 1.4 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.92 | 20 mg/m2 p.o. q2wk with prednisolone; or 2-6 mg/m2 q24-48h. 1.4 mg/kg p.o. as single dose as substitute for cyclophosphamide in CHOP-type protocols. • |
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Alkylates DNA, forming cross-links that inhibit DNA replication and transcription. Slow-acting with relatively mild myelosuppression.
Cytotoxic — handler precautions required (gloves). Myelosuppression (monitor CBC q2 weeks initially). Commonly used for feline small cell lymphoma and IBD. Well-tolerated in cats.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Chlorambucil dose range in dogs, with cited source references: PO 4–6 mg/m2 q24-48h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Chlorambucil in dogs: PO.
Cited course lengths for Chlorambucil in dogs include: Per protocol. Duration depends on the indication — match it to the specific dose rule in the table above.
Chlorambucil is indicated in dogs for: Lymphoma (COP protocol component), CLL.
These are general warnings for Chlorambucil across species; consult the dog dosing table above for species-specific guidance. Cytotoxic — handler precautions required (gloves). Myelosuppression (monitor CBC q2 weeks initially). Commonly used for feline small cell lymphoma and IBD. Well-tolerated in cats.
Why a species-specific page? Chlorambucil pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 0.1–0.2 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.92 | gus complex (in combination with corticosteroids): 0.1-0.2 mg/kg p.o. q24h initially until marked improvement of clinical signs; then alternate-day dosing |
| 0.1–0.2 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.176 | q24h initially, then q48h PO. (Equivalent dose is 0.1-0.2 mg/kg.) |
| Dose (mg/m2) | Route | Source | As printed |
|---|---|---|---|
| 4 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.176 | • 4 mg/m2 q24h, PO, continuous treatment (metronomic dose protocol). 2-6 mg/m2 |
| 2–6 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.176 | • 4 mg/m2 q24h, PO, continuous treatment (metronomic dose protocol). 2-6 mg/m2 |
| 4–6 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.176 | • Intestinal disease: Start with 4-6 mg/m2, PO, q24, for first 7-21 days, then |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.