Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Hydroxyurea is dosed at 50–60 mg/kg PO q24h initially, then taper to every other day in dogs, per Withrow & MacEwen's Small Animal Clinical Oncology, 5th Ed (2013) - held; rule cites 6th Ed - corpus p.186 (printed p.172), Ch.11; corroborated by Plumb's Veterinary Drug Handbook 10th Ed, corpus p.656 (printed p.629), DOGS: 30-60 mg/kg PO once daily. Hydroxyurea is used in dogs for Polycythemia vera / CML / meningioma. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Hydroxyurea in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Hydrea, Droxia
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 50–60 mg/kg | q24h initially, then taper to every other day | Chronic use; titrate based on CBC | Polycythemia vera / CML / meningioma | Moderate | Withrow & MacEwen's Small Animal Clinical Oncology, 5th Ed (2013) - held; rule cites 6th Ed - corpus p.186 (printed p.172), Ch.11; corroborated by Plumb's Veterinary Drug Handbook 10th Ed, corpus p.656 (printed p.629), DOGS: 30-60 mg/kg PO once daily |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits ribonucleotide reductase, blocking conversion of ribonucleotides to deoxyribonucleotides. S-phase specific. Reduces elevated cell counts rapidly.
Myelosuppression is dose-dependent and predictable. Monitor CBC weekly initially. Megaloblastic changes expected. Used for polycythemia vera, CML, and meningioma in dogs and cats.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Hydroxyurea dose range in dogs, with cited source references: PO 50–60 mg/kg q24h initially, then taper to every other day. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Hydroxyurea in dogs: PO.
Cited course lengths for Hydroxyurea in dogs include: Chronic use; titrate based on CBC. Duration depends on the indication — match it to the specific dose rule in the table above.
Hydroxyurea is indicated in dogs for: Polycythemia vera / CML / meningioma.
These are general warnings for Hydroxyurea across species; consult the dog dosing table above for species-specific guidance. Myelosuppression is dose-dependent and predictable. Monitor CBC weekly initially. Megaloblastic changes expected. Used for polycythemia vera, CML, and meningioma in dogs and cats.
Why a species-specific page? Hydroxyurea pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.