Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Hydroxyurea is used in dog for Polycythemia vera / CML / meningioma. Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Hydroxyurea in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Hydrea, Droxia
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 50–80 mg/kg | 50mg/kg PO q24h (some protocols q48h) | Chronic use; titrate based on CBC | Polycythemia vera / CML / meningioma | Moderate | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits ribonucleotide reductase, blocking conversion of ribonucleotides to deoxyribonucleotides. S-phase specific. Reduces elevated cell counts rapidly.
Myelosuppression is dose-dependent and predictable. Monitor CBC weekly initially. Megaloblastic changes expected. Used for polycythemia vera, CML, and meningioma in dogs and cats.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Hydroxyurea pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.