Cat · Felis catus · typical adult weight 2.50–7.00 kg
Hydroxyurea is dosed at 25 mg/kg PO 3 times weekly (q48-72h) in cats, per BSAVA Small Animal Formulary 10th Ed, Part A (Canine and Feline), Hydroxycarbamide (Hydroxyurea), DOSES - Cats, corpus p.215 (printed p.199). Hydroxyurea is used in cats for Myeloproliferative disease / polycythemia vera. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Hydroxyurea in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Hydrea, Droxia
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 25 mg/kg | 3 times weekly (q48-72h) | Chronic use; intensive CBC monitoring | Myeloproliferative disease / polycythemia vera | Moderate | BSAVA Small Animal Formulary 10th Ed, Part A (Canine and Feline), Hydroxycarbamide (Hydroxyurea), DOSES - Cats, corpus p.215 (printed p.199) |
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Inhibits ribonucleotide reductase, blocking conversion of ribonucleotides to deoxyribonucleotides. S-phase specific. Reduces elevated cell counts rapidly.
Myelosuppression is dose-dependent and predictable. Monitor CBC weekly initially. Megaloblastic changes expected. Used for polycythemia vera, CML, and meningioma in dogs and cats.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Hydroxyurea dose range in cats, with cited source references: PO 25 mg/kg 3 times weekly (q48-72h). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Hydroxyurea in cats: PO.
Cited course lengths for Hydroxyurea in cats include: Chronic use; intensive CBC monitoring. Duration depends on the indication — match it to the specific dose rule in the table above.
Hydroxyurea is indicated in cats for: Myeloproliferative disease / polycythemia vera.
These are general warnings for Hydroxyurea across species; consult the cat dosing table above for species-specific guidance. Myelosuppression is dose-dependent and predictable. Monitor CBC weekly initially. Megaloblastic changes expected. Used for polycythemia vera, CML, and meningioma in dogs and cats.
Why a species-specific page? Hydroxyurea pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.