Cat · Felis catus · typical adult weight 2.50–7.00 kg
Mitoxantrone is dosed at 6–6.5 mg/m2 IV q21 days in cats, per Cunha SCS, Corgozinho KB, Souza HJM, Silva K, Ferreira AMR. Adjuvant chemotherapy with mitoxantrone for cats with mammary carcinomas treated with radical mastectomy. J Feline Med Surg. 2015;17(12):1000-1004. doi:10.1177/1098612x14567159 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.930 (2026-08-01). — Plumb's 10th ed (held) printed p.902, Mitoxantrone monograph spanning p.902-903; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Mitoxantrone is used in cats for Lymphoma, carcinomas. Routes documented in cats: IV. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Mitoxantrone in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Novantrone
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 6–6.5 mg/m2 | q21 days | 4-6 cycles | Lymphoma, carcinomas | Moderate | Cunha SCS, Corgozinho KB, Souza HJM, Silva K, Ferreira AMR. Adjuvant chemotherapy with mitoxantrone for cats with mammary carcinomas treated with radical mastectomy. J Feline Med Surg. 2015;17(12):1000-1004. doi:10.1177/1098612x14567159 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.930 (2026-08-01). — Plumb's 10th ed (held) printed p.902, Mitoxantrone monograph spanning p.902-903; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/m2) | Route | Source | As printed |
|---|---|---|---|
| 6–6.5 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.569 | • 6-6.5 mg/m2 IV every 21 days. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Intercalates DNA and inhibits topoisomerase II. Related to anthracyclines but less cardiotoxic. Also disrupts RNA synthesis.
Less cardiotoxic than doxorubicin — used as alternative. Myelosuppression dose-limiting. Blue-green discoloration of urine/sclera. Safe in cats (unlike cisplatin).
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Mitoxantrone dose range in cats, with cited source references: IV 6–6.5 mg/m2 q21 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Mitoxantrone in cats: IV.
Cited course lengths for Mitoxantrone in cats include: 4-6 cycles. Duration depends on the indication — match it to the specific dose rule in the table above.
Mitoxantrone is indicated in cats for: Lymphoma, carcinomas.
These are general warnings for Mitoxantrone across species; consult the cat dosing table above for species-specific guidance. Less cardiotoxic than doxorubicin — used as alternative. Myelosuppression dose-limiting. Blue-green discoloration of urine/sclera. Safe in cats (unlike cisplatin).
Why a species-specific page? Mitoxantrone pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.