Cat · Felis catus · typical adult weight 2.50–7.00 kg
Mitoxantrone is dosed at 6–6.5 mg/m2 IV q21 days in cats, per Cunha SCS, Corgozinho KB, Souza HJM, Silva K, Ferreira AMR. Adjuvant chemotherapy with mitoxantrone for cats with mammary carcinomas treated with radical mastectomy. J Feline Med Surg. 2015;17(12):1000-1004. doi:10.1177/1098612x14567159 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.930 (2026-08-01).. Mitoxantrone is used in cats for Lymphoma, carcinomas. Routes documented in cats: IV. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Mitoxantrone in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Novantrone
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 6–6.5 mg/m2 | q21 days | 4-6 cycles | Lymphoma, carcinomas | Moderate | Cunha SCS, Corgozinho KB, Souza HJM, Silva K, Ferreira AMR. Adjuvant chemotherapy with mitoxantrone for cats with mammary carcinomas treated with radical mastectomy. J Feline Med Surg. 2015;17(12):1000-1004. doi:10.1177/1098612x14567159 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.930 (2026-08-01). |
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Intercalates DNA and inhibits topoisomerase II. Related to anthracyclines but less cardiotoxic. Also disrupts RNA synthesis.
Less cardiotoxic than doxorubicin — used as alternative. Myelosuppression dose-limiting. Blue-green discoloration of urine/sclera. Safe in cats (unlike cisplatin).
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Mitoxantrone dose range in cats, with cited source references: IV 6–6.5 mg/m2 q21 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Mitoxantrone in cats: IV.
Cited course lengths for Mitoxantrone in cats include: 4-6 cycles. Duration depends on the indication — match it to the specific dose rule in the table above.
Mitoxantrone is indicated in cats for: Lymphoma, carcinomas.
These are general warnings for Mitoxantrone across species; consult the cat dosing table above for species-specific guidance. Less cardiotoxic than doxorubicin — used as alternative. Myelosuppression dose-limiting. Blue-green discoloration of urine/sclera. Safe in cats (unlike cisplatin).
Why a species-specific page? Mitoxantrone pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.