Cat · Felis catus · typical adult weight 2.50–7.00 kg
Melphalan is dosed at 0.05–0.1 mg/kg PO q24h x 10 days then q48h in cats, per Hanna F: Multiple myelomas in cats, J Feline Med Surg 7:275-287, 2005. / 26. Drazner FH: Multiple myeloma in the cat, Comp Cont Ed Pract Vet 4:206-216, 1982. — Verified against Withrow & MacEwen's Small Animal Clinical Oncology, 5th Ed, p.685 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.685' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.671; verified by finding the drug named there. If you are holding the book, turn to p.671. — SOURCE EDITION: Withrow and MacEwen's Small Animal Clinical Oncology — ISBN 9781437723625, https://openlibrary.org/isbn/9781437723625. Melphalan is used in cats for Multiple myeloma. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Melphalan in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Alkeran
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.05–0.1 mg/kg | q24h x 10 days then q48h | Long-term | Multiple myeloma | Moderate | Hanna F: Multiple myelomas in cats, J Feline Med Surg 7:275-287, 2005. / 26. Drazner FH: Multiple myeloma in the cat, Comp Cont Ed Pract Vet 4:206-216, 1982. — Verified against Withrow & MacEwen's Small Animal Clinical Oncology, 5th Ed, p.685 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.685' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.671; verified by finding the drug named there. If you are holding the book, turn to p.671. — SOURCE EDITION: Withrow and MacEwen's Small Animal Clinical Oncology — ISBN 9781437723625, https://openlibrary.org/isbn/9781437723625 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.1 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.269 | 0.1 mg/kg p.o. q24h for 14 days then q48h until improvement or leucopenia detected. Cats alre |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Bifunctional alkylating agent forming DNA interstrand crosslinks. Cell-cycle non-specific. Phenylalanine derivative of nitrogen mustard.
Delayed and cumulative myelosuppression. Take on empty stomach. Used for multiple myeloma, various carcinomas. Handle with gloves — vesicant. Carcinogenic to handlers.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Melphalan dose range in cats, with cited source references: PO 0.05–0.1 mg/kg q24h x 10 days then q48h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Melphalan in cats: PO.
Cited course lengths for Melphalan in cats include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Melphalan is indicated in cats for: Multiple myeloma.
These are general warnings for Melphalan across species; consult the cat dosing table above for species-specific guidance. Delayed and cumulative myelosuppression. Take on empty stomach. Used for multiple myeloma, various carcinomas. Handle with gloves — vesicant. Carcinogenic to handlers.
Why a species-specific page? Melphalan pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.