Cat · Felis catus · typical adult weight 2.50–7.00 kg
Melphalan is dosed at 0.05–0.1 mg/kg PO q24h x 10 days then q48h in cats, per Hanna F: Multiple myelomas in cats, J Feline Med Surg 7:275-287, 2005. / 26. Drazner FH: Multiple myeloma in the cat, Comp Cont Ed Pract Vet 4:206-216, 1982. — Verified against Withrow & MacEwen's Small Animal Clinical Oncology, 5th Ed, p.685 (2026-08-01).. Melphalan is used in cats for Multiple myeloma. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Melphalan in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Alkeran
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.05–0.1 mg/kg | q24h x 10 days then q48h | Long-term | Multiple myeloma | Moderate | Hanna F: Multiple myelomas in cats, J Feline Med Surg 7:275-287, 2005. / 26. Drazner FH: Multiple myeloma in the cat, Comp Cont Ed Pract Vet 4:206-216, 1982. — Verified against Withrow & MacEwen's Small Animal Clinical Oncology, 5th Ed, p.685 (2026-08-01). |
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Bifunctional alkylating agent forming DNA interstrand crosslinks. Cell-cycle non-specific. Phenylalanine derivative of nitrogen mustard.
Delayed and cumulative myelosuppression. Take on empty stomach. Used for multiple myeloma, various carcinomas. Handle with gloves — vesicant. Carcinogenic to handlers.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Melphalan dose range in cats, with cited source references: PO 0.05–0.1 mg/kg q24h x 10 days then q48h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Melphalan in cats: PO.
Cited course lengths for Melphalan in cats include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Melphalan is indicated in cats for: Multiple myeloma.
These are general warnings for Melphalan across species; consult the cat dosing table above for species-specific guidance. Delayed and cumulative myelosuppression. Take on empty stomach. Used for multiple myeloma, various carcinomas. Handle with gloves — vesicant. Carcinogenic to handlers.
Why a species-specific page? Melphalan pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.