Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Melphalan is dosed at 0.05–0.1 mg/kg PO q24h x 10 days, then q48h in dogs, per MELPHALAN HYDROCHLORIDE Kit [US Product Label]. Princeton, NJ: Fosun Pharma USA Inc; 2019.; ALKERAN - Melphalan Tablet, Film Coated [US Human Product Label]. Weston, FL: ApoPharma USA, In; 2017. (the 10-day regimen sentence itself carries no superscript; the neighbouring general-guide sentence '...1.5 - 2 mg/m2 (NOT mg/kg) or 0.1 - 0.2 mg/kg in dogs, but higher dosages have been used.8,9' carries refs 8 and 9) — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.857 (2026-08-01).. Melphalan is used in dogs for Multiple myeloma. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Melphalan in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Alkeran
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.05–0.1 mg/kg | q24h x 10 days, then q48h | Long-term | Multiple myeloma | Strong | MELPHALAN HYDROCHLORIDE Kit [US Product Label]. Princeton, NJ: Fosun Pharma USA Inc; 2019.; ALKERAN - Melphalan Tablet, Film Coated [US Human Product Label]. Weston, FL: ApoPharma USA, In; 2017. (the 10-day regimen sentence itself carries no superscript; the neighbouring general-guide sentence '...1.5 - 2 mg/m2 (NOT mg/kg) or 0.1 - 0.2 mg/kg in dogs, but higher dosages have been used.8,9' carries refs 8 and 9) — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.857 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Bifunctional alkylating agent forming DNA interstrand crosslinks. Cell-cycle non-specific. Phenylalanine derivative of nitrogen mustard.
Delayed and cumulative myelosuppression. Take on empty stomach. Used for multiple myeloma, various carcinomas. Handle with gloves — vesicant. Carcinogenic to handlers.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Melphalan dose range in dogs, with cited source references: PO 0.05–0.1 mg/kg q24h x 10 days, then q48h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Melphalan in dogs: PO.
Cited course lengths for Melphalan in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Melphalan is indicated in dogs for: Multiple myeloma.
These are general warnings for Melphalan across species; consult the dog dosing table above for species-specific guidance. Delayed and cumulative myelosuppression. Take on empty stomach. Used for multiple myeloma, various carcinomas. Handle with gloves — vesicant. Carcinogenic to handlers.
Why a species-specific page? Melphalan pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.