Melphalan for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Melphalan is used in dog for Multiple myeloma. Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Melphalan in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Alkeran
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.05–0.1 mg/kg | q24h x 10 days, then q48h | Long-term | Multiple myeloma | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Bifunctional alkylating agent forming DNA interstrand crosslinks. Cell-cycle non-specific. Phenylalanine derivative of nitrogen mustard.
Side effects & warnings
Delayed and cumulative myelosuppression. Take on empty stomach. Used for multiple myeloma, various carcinomas. Handle with gloves — vesicant. Carcinogenic to handlers.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Oncology drugs with dog dosing
Melphalan dosing in other species
Why a species-specific page? Melphalan pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.