Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Dacarbazine is used in dog for Relapsed lymphoma (DMAC protocol). Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Dacarbazine in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: DTIC-Dome
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 200 mg/m2 | per DMAC protocol schedule | Protocol-dependent | Relapsed lymphoma (DMAC protocol) | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Prodrug metabolized to active alkylating metabolite that methylates DNA at O6 and N7 guanine positions. Cell-cycle non-specific.
Used for relapsed lymphoma (DMAC protocol). Severe nausea/vomiting. Vesicant — extravasation causes tissue necrosis. Hepatic veno-occlusive disease reported. Light sensitive.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Dacarbazine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.