Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Dacarbazine is dosed at 200 mg/m2 IV per DMAC protocol schedule in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.360 (2026-08-01).. Dacarbazine is used in dogs for Relapsed lymphoma (DMAC protocol). Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Dacarbazine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: DTIC-Dome
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 200 mg/m2 | per DMAC protocol schedule | Protocol-dependent | Relapsed lymphoma (DMAC protocol) | Moderate | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.360 (2026-08-01). |
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Prodrug metabolized to active alkylating metabolite that methylates DNA at O6 and N7 guanine positions. Cell-cycle non-specific.
Used for relapsed lymphoma (DMAC protocol). Severe nausea/vomiting. Vesicant — extravasation causes tissue necrosis. Hepatic veno-occlusive disease reported. Light sensitive.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Dacarbazine dose range in dogs, with cited source references: IV 200 mg/m2 per DMAC protocol schedule. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Dacarbazine in dogs: IV.
Cited course lengths for Dacarbazine in dogs include: Protocol-dependent. Duration depends on the indication — match it to the specific dose rule in the table above.
Dacarbazine is indicated in dogs for: Relapsed lymphoma (DMAC protocol).
These are general warnings for Dacarbazine across species; consult the dog dosing table above for species-specific guidance. Used for relapsed lymphoma (DMAC protocol). Severe nausea/vomiting. Vesicant — extravasation causes tissue necrosis. Hepatic veno-occlusive disease reported. Light sensitive.
Why a species-specific page? Dacarbazine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.