ExoticRx · exoticrx.com/drugs/dacarbazine
Dacarbazine
DTIC-Dome
Drug Class
Routes
Indications
Mechanism of Action
Prodrug metabolized to active alkylating metabolite that methylates DNA at O6 and N7 guanine positions. Cell-cycle non-specific.
Side effects & warnings
Used for relapsed lymphoma (DMAC protocol). Severe nausea/vomiting. Vesicant — extravasation causes tissue necrosis. Hepatic veno-occlusive disease reported. Light sensitive.
Species with Dacarbazine dosing data (1 dose rule)
Species references:All Dog (Domestic) drugs
Evidence levels across 1 dose rule
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Backed by a published source
- · Plumb's Veterinary Drug Handbook, 9th Ed
Sample dosing (1 of 1 cited rule)
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 200 mg/m2 | per DMAC protocol schedule | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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Source citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.