ExoticRx · exoticrx.com/drugs/dacarbazine
US brand names:DTIC-Dome
Dacarbazine is dosed at 200 mg/m2 IV per DMAC protocol schedule in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.360 (2026-08-01).. Verify against current literature before clinical use.
Prodrug metabolized to active alkylating metabolite that methylates DNA at O6 and N7 guanine positions. Cell-cycle non-specific.
Used for relapsed lymphoma (DMAC protocol). Severe nausea/vomiting. Vesicant — extravasation causes tissue necrosis. Hepatic veno-occlusive disease reported. Light sensitive.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 200 mg/m2 | per DMAC protocol schedule | Moderate | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.360 (2026-08-01). |
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