Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Epirubicin is dosed at 25–30 mg/m2 IV q21 days in dogs, per Mason SL, Finotello R, Blackwood L. Epirubicin in the treatment of canine histiocytic sarcoma: sequential, alternating and rescue chemotherapy. Vet Comp Oncol. 2018;16(1):E30-E37. doi:10.1111/vco.12329 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.489 (2026-08-01). — Plumb's 10th ed (held) printed p.460, Epirubicin monograph spanning p.460-462; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Epirubicin is used in dogs for Lymphoma (alternative to doxorubicin). Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Epirubicin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Ellence
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 25–30 mg/m2 | q21 days | 4-6 cycles | Lymphoma (alternative to doxorubicin) | Moderate | Mason SL, Finotello R, Blackwood L. Epirubicin in the treatment of canine histiocytic sarcoma: sequential, alternating and rescue chemotherapy. Vet Comp Oncol. 2018;16(1):E30-E37. doi:10.1111/vco.12329 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.489 (2026-08-01). — Plumb's 10th ed (held) printed p.460, Epirubicin monograph spanning p.460-462; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 1 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.167 | not to exceed 240 mg/m2. In dogs weighing <10 kg a dose of 1 mg/kg should be used |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Epimer of doxorubicin. Intercalates DNA, inhibits topoisomerase II, generates free radicals. Possibly less cardiotoxic than doxorubicin.
Vesicant — severe tissue necrosis with extravasation. Cumulative cardiotoxicity (monitor echocardiography). Myelosuppression. Alopecia in breeds with continuously growing hair.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Epirubicin dose range in dogs, with cited source references: IV 25–30 mg/m2 q21 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Epirubicin in dogs: IV.
Cited course lengths for Epirubicin in dogs include: 4-6 cycles. Duration depends on the indication — match it to the specific dose rule in the table above.
Epirubicin is indicated in dogs for: Lymphoma (alternative to doxorubicin).
These are general warnings for Epirubicin across species; consult the dog dosing table above for species-specific guidance. Vesicant — severe tissue necrosis with extravasation. Cumulative cardiotoxicity (monitor echocardiography). Myelosuppression. Alopecia in breeds with continuously growing hair.
Why a species-specific page? Epirubicin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.