Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Epirubicin is dosed at 25–30 mg/m2 IV q21 days in dogs, per Mason SL, Finotello R, Blackwood L. Epirubicin in the treatment of canine histiocytic sarcoma: sequential, alternating and rescue chemotherapy. Vet Comp Oncol. 2018;16(1):E30-E37. doi:10.1111/vco.12329 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.489 (2026-08-01).. Epirubicin is used in dogs for Lymphoma (alternative to doxorubicin). Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Epirubicin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Ellence
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 25–30 mg/m2 | q21 days | 4-6 cycles | Lymphoma (alternative to doxorubicin) | Moderate | Mason SL, Finotello R, Blackwood L. Epirubicin in the treatment of canine histiocytic sarcoma: sequential, alternating and rescue chemotherapy. Vet Comp Oncol. 2018;16(1):E30-E37. doi:10.1111/vco.12329 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.489 (2026-08-01). |
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Epimer of doxorubicin. Intercalates DNA, inhibits topoisomerase II, generates free radicals. Possibly less cardiotoxic than doxorubicin.
Vesicant — severe tissue necrosis with extravasation. Cumulative cardiotoxicity (monitor echocardiography). Myelosuppression. Alopecia in breeds with continuously growing hair.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Epirubicin dose range in dogs, with cited source references: IV 25–30 mg/m2 q21 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Epirubicin in dogs: IV.
Cited course lengths for Epirubicin in dogs include: 4-6 cycles. Duration depends on the indication — match it to the specific dose rule in the table above.
Epirubicin is indicated in dogs for: Lymphoma (alternative to doxorubicin).
These are general warnings for Epirubicin across species; consult the dog dosing table above for species-specific guidance. Vesicant — severe tissue necrosis with extravasation. Cumulative cardiotoxicity (monitor echocardiography). Myelosuppression. Alopecia in breeds with continuously growing hair.
Why a species-specific page? Epirubicin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.