ExoticRx · exoticrx.com/drugs/epirubicin
US brand names:Ellence
Epirubicin is dosed at 25–30 mg/m2 IV q21 days in dogs, per Mason SL, Finotello R, Blackwood L. Epirubicin in the treatment of canine histiocytic sarcoma: sequential, alternating and rescue chemotherapy. Vet Comp Oncol. 2018;16(1):E30-E37. doi:10.1111/vco.12329 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.489 (2026-08-01).. Verify against current literature before clinical use.
Epimer of doxorubicin. Intercalates DNA, inhibits topoisomerase II, generates free radicals. Possibly less cardiotoxic than doxorubicin.
Vesicant — severe tissue necrosis with extravasation. Cumulative cardiotoxicity (monitor echocardiography). Myelosuppression. Alopecia in breeds with continuously growing hair.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 25–30 mg/m2 | q21 days | Moderate | Mason SL, Finotello R, Blackwood L. Epirubicin in the treatment of canine histiocytic sarcoma: sequential, alternating and rescue chemotherapy. Vet Comp Oncol. 2018;16(1):E30-E37. doi:10.1111/vco.12329 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.489 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.