Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Ifosfamide is dosed at 350–375 mg/m2 IV q21 days in dogs, per Brewer W. New, promising chemotherapy agents. Presented at: Western Veterinary Conference; 2003. Distributed by John Wiley & Sons, Inc. PMID: 40190668 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.663 (2026-08-01).. Ifosfamide is used in dogs for Sarcomas, lymphoma rescue. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Ifosfamide in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Ifex
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 350–375 mg/m2 | q21 days | 4-6 cycles | Sarcomas, lymphoma rescue | Moderate | Brewer W. New, promising chemotherapy agents. Presented at: Western Veterinary Conference; 2003. Distributed by John Wiley & Sons, Inc. PMID: 40190668 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.663 (2026-08-01). |
Need the exact dose for your patient?
Enter your dog's weight to check these cited ranges in the calculator — unit and concentration math done for you.
Prodrug activated by hepatic CYP enzymes to form alkylating metabolites. Cross-links DNA strands. Related to cyclophosphamide.
MUST co-administer mesna to prevent hemorrhagic cystitis (more urotoxic than cyclophosphamide). Myelosuppression. Neurotoxicity (encephalopathy). Saline diuresis required.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Ifosfamide dose range in dogs, with cited source references: IV 350–375 mg/m2 q21 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Ifosfamide in dogs: IV.
Cited course lengths for Ifosfamide in dogs include: 4-6 cycles. Duration depends on the indication — match it to the specific dose rule in the table above.
Ifosfamide is indicated in dogs for: Sarcomas, lymphoma rescue.
These are general warnings for Ifosfamide across species; consult the dog dosing table above for species-specific guidance. MUST co-administer mesna to prevent hemorrhagic cystitis (more urotoxic than cyclophosphamide). Myelosuppression. Neurotoxicity (encephalopathy). Saline diuresis required.
Why a species-specific page? Ifosfamide pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.