Ifosfamide for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Ifosfamide is used in dog for Sarcomas, lymphoma rescue. Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Ifosfamide in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Ifex
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 350–375 mg/m2 | q21 days | 4-6 cycles | Sarcomas, lymphoma rescue | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Prodrug activated by hepatic CYP enzymes to form alkylating metabolites. Cross-links DNA strands. Related to cyclophosphamide.
Side effects & warnings
MUST co-administer mesna to prevent hemorrhagic cystitis (more urotoxic than cyclophosphamide). Myelosuppression. Neurotoxicity (encephalopathy). Saline diuresis required.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Oncology drugs with dog dosing
Why a species-specific page? Ifosfamide pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.