ExoticRx · exoticrx.com/drugs/ifosfamide
US brand names:Ifex
Ifosfamide is dosed at 350–375 mg/m2 IV q21 days in dogs, per Brewer W. New, promising chemotherapy agents. Presented at: Western Veterinary Conference; 2003. Distributed by John Wiley & Sons, Inc. PMID: 40190668 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.663 (2026-08-01).. Verify against current literature before clinical use.
Prodrug activated by hepatic CYP enzymes to form alkylating metabolites. Cross-links DNA strands. Related to cyclophosphamide.
MUST co-administer mesna to prevent hemorrhagic cystitis (more urotoxic than cyclophosphamide). Myelosuppression. Neurotoxicity (encephalopathy). Saline diuresis required.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 350–375 mg/m2 | q21 days | Moderate | Brewer W. New, promising chemotherapy agents. Presented at: Western Veterinary Conference; 2003. Distributed by John Wiley & Sons, Inc. PMID: 40190668 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.663 (2026-08-01). |
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