ExoticRx · exoticrx.com/drugs/ifosfamide
Ifex
Prodrug activated by hepatic CYP enzymes to form alkylating metabolites. Cross-links DNA strands. Related to cyclophosphamide.
MUST co-administer mesna to prevent hemorrhagic cystitis (more urotoxic than cyclophosphamide). Myelosuppression. Neurotoxicity (encephalopathy). Saline diuresis required.
Species references:All Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 350–375 mg/m2 | q21 days | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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