Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Cyclophosphamide is dosed at 200–300 mg/m2 PO q21d or 50 mg/m2 daily x4 days/week in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Cyclophosphamide is used in dogs for Lymphoma (CHOP), immune-mediated diseases. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Cyclophosphamide in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Cytoxan
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 200–300 mg/m2 | q21d or 50 mg/m2 daily x4 days/week | Per protocol | Lymphoma (CHOP), immune-mediated diseases | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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Prodrug activated by hepatic CYP enzymes to form phosphoramide mustard, which alkylates DNA, cross-linking strands and inhibiting replication.
Sterile hemorrhagic cystitis from metabolite acrolein — concurrent furosemide/mesna and adequate hydration recommended. Myelosuppression. Handler precautions. Also used for immune-mediated diseases.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Cyclophosphamide dose range in dogs, with cited source references: PO 200–300 mg/m2 q21d or 50 mg/m2 daily x4 days/week. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Cyclophosphamide in dogs: PO.
Cited course lengths for Cyclophosphamide in dogs include: Per protocol. Duration depends on the indication — match it to the specific dose rule in the table above.
Cyclophosphamide is indicated in dogs for: Lymphoma (CHOP), immune-mediated diseases.
These are general warnings for Cyclophosphamide across species; consult the dog dosing table above for species-specific guidance. Sterile hemorrhagic cystitis from metabolite acrolein — concurrent furosemide/mesna and adequate hydration recommended. Myelosuppression. Handler precautions. Also used for immune-mediated diseases.
Why a species-specific page? Cyclophosphamide pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.