Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Doxorubicin is dosed at 30 mg/m2 IV q21d in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.459 (2026-08-01).. Doxorubicin is used in dogs for Lymphoma, hemangiosarcoma, osteosarcoma. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Doxorubicin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Adriamycin
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 30 mg/m2 | q21d | 4-6 cycles (max lifetime 240 mg/m2) | Lymphoma, hemangiosarcoma, osteosarcoma | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.459 (2026-08-01). |
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Intercalates DNA, inhibits topoisomerase II, and generates free radicals. Multiple mechanisms of cytotoxicity against rapidly dividing cells.
VESICANT — extravasation causes severe tissue necrosis (apply cold, dexrazoxane if available). Cumulative cardiotoxicity (max lifetime dose ~240mg/m2 in dogs). Myelosuppression. Anaphylaxis risk in dogs (premedicate with antihistamine). Cats: nephrotoxic.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Doxorubicin dose range in dogs, with cited source references: IV 30 mg/m2 q21d. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Doxorubicin in dogs: IV.
Cited course lengths for Doxorubicin in dogs include: 4-6 cycles (max lifetime 240 mg/m2). Duration depends on the indication — match it to the specific dose rule in the table above.
Doxorubicin is indicated in dogs for: Lymphoma, hemangiosarcoma, osteosarcoma.
These are general warnings for Doxorubicin across species; consult the dog dosing table above for species-specific guidance. VESICANT — extravasation causes severe tissue necrosis (apply cold, dexrazoxane if available). Cumulative cardiotoxicity (max lifetime dose ~240mg/m2 in dogs). Myelosuppression. Anaphylaxis risk in dogs (premedicate with antihistamine). Cats: nephrotoxic.
Why a species-specific page? Doxorubicin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.