Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Doxorubicin is dosed at 30 mg/m2 IV q21d in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.459 (2026-08-01). — Plumb's 10th ed (held) printed p.432, Doxorubicin monograph spanning p.430-432; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Doxorubicin is used in dogs for Lymphoma, hemangiosarcoma, osteosarcoma. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Doxorubicin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Adriamycin
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 30 mg/m2 | q21d | 4-6 cycles (max lifetime 240 mg/m2) | Lymphoma, hemangiosarcoma, osteosarcoma | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.459 (2026-08-01). — Plumb's 10th ed (held) printed p.432, Doxorubicin monograph spanning p.430-432; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 1 | IM | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.156 | 30 mg/m2 i.v. q3wk. In dogs weighing <10 kg a dose of 1 mg/kg should be used. Maximum total dose not to exceed 240 mg/m2 |
| 1 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.302 | • Dogs ,15 kg body weight: 1 mg/kg. |
| Dose (mg/m2) | Route | Source | As printed |
|---|---|---|---|
| 30 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.302 | • 30 mg/m2 q21days IV. |
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Intercalates DNA, inhibits topoisomerase II, and generates free radicals. Multiple mechanisms of cytotoxicity against rapidly dividing cells.
VESICANT — extravasation causes severe tissue necrosis (apply cold, dexrazoxane if available). Cumulative cardiotoxicity (max lifetime dose ~240mg/m2 in dogs). Myelosuppression. Anaphylaxis risk in dogs (premedicate with antihistamine). Cats: nephrotoxic.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Doxorubicin dose range in dogs, with cited source references: IV 30 mg/m2 q21d. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Doxorubicin in dogs: IV.
Cited course lengths for Doxorubicin in dogs include: 4-6 cycles (max lifetime 240 mg/m2). Duration depends on the indication — match it to the specific dose rule in the table above.
Doxorubicin is indicated in dogs for: Lymphoma, hemangiosarcoma, osteosarcoma.
These are general warnings for Doxorubicin across species; consult the dog dosing table above for species-specific guidance. VESICANT — extravasation causes severe tissue necrosis (apply cold, dexrazoxane if available). Cumulative cardiotoxicity (max lifetime dose ~240mg/m2 in dogs). Myelosuppression. Anaphylaxis risk in dogs (premedicate with antihistamine). Cats: nephrotoxic.
Why a species-specific page? Doxorubicin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 30 |
| — |
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.302 |
| • Dogs .15 kg body weight: 30 mg/m2. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.