Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Everolimus is used in dog for Solid tumors (mTOR pathway activated). Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Everolimus in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Afinitor
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2–5 mg/kg | PO q24h | Chronic use; monitor drug levels if available | Solid tumors (mTOR pathway activated) | Anecdotal | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits mTOR (mammalian target of rapamycin) by binding FKBP-12. Blocks downstream signaling from PI3K/AKT pathway, inhibiting cell growth, proliferation, and angiogenesis.
Immunosuppression — monitor for infections. Stomatitis common. Metabolic effects: hyperglycemia, hyperlipidemia. Non-infectious pneumonitis. Limited veterinary data.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Everolimus pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.