Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Everolimus is dosed at 2–5 mg/kg PO PO q24h in dogs, per Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed. Everolimus is used in dogs for Solid tumors (mTOR pathway activated). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Everolimus in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Afinitor
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2–5 mg/kg | PO q24h | Chronic use; monitor drug levels if available | Solid tumors (mTOR pathway activated) | Anecdotal | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits mTOR (mammalian target of rapamycin) by binding FKBP-12. Blocks downstream signaling from PI3K/AKT pathway, inhibiting cell growth, proliferation, and angiogenesis.
Immunosuppression — monitor for infections. Stomatitis common. Metabolic effects: hyperglycemia, hyperlipidemia. Non-infectious pneumonitis. Limited veterinary data.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Everolimus dose range in dogs, with cited source references: PO 2–5 mg/kg PO q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Everolimus in dogs: PO.
Cited course lengths for Everolimus in dogs include: Chronic use; monitor drug levels if available. Duration depends on the indication — match it to the specific dose rule in the table above.
Everolimus is indicated in dogs for: Solid tumors (mTOR pathway activated).
These are general warnings for Everolimus across species; consult the dog dosing table above for species-specific guidance. Immunosuppression — monitor for infections. Stomatitis common. Metabolic effects: hyperglycemia, hyperlipidemia. Non-infectious pneumonitis. Limited veterinary data.
Why a species-specific page? Everolimus pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.