ExoticRx · exoticrx.com/drugs/everolimus
US brand names:Afinitor
Everolimus is dosed at 2–5 mg/kg PO PO q24h in dogs, per Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed. Verify against current literature before clinical use.
Inhibits mTOR (mammalian target of rapamycin) by binding FKBP-12. Blocks downstream signaling from PI3K/AKT pathway, inhibiting cell growth, proliferation, and angiogenesis.
Immunosuppression — monitor for infections. Stomatitis common. Metabolic effects: hyperglycemia, hyperlipidemia. Non-infectious pneumonitis. Limited veterinary data.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.