ExoticRx · exoticrx.com/drugs/doxorubicin
US brand names:Adriamycin
Doxorubicin is dosed at 30 mg/m2 IV q21d in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.459 (2026-08-01).. Verify against current literature before clinical use.
Intercalates DNA, inhibits topoisomerase II, and generates free radicals. Multiple mechanisms of cytotoxicity against rapidly dividing cells.
VESICANT — extravasation causes severe tissue necrosis (apply cold, dexrazoxane if available). Cumulative cardiotoxicity (max lifetime dose ~240mg/m2 in dogs). Myelosuppression. Anaphylaxis risk in dogs (premedicate with antihistamine). Cats: nephrotoxic.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.