Cat · Felis catus · typical adult weight 2.50–7.00 kg
Cyclophosphamide is dosed at 200–300 mg/m2 PO q21d in cats, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.318, Cyclophosphamide monograph spanning p.318-321; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Cyclophosphamide is used in cats for Lymphoma. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Cyclophosphamide in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Cytoxan
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 200–300 mg/m2 | q21d | Per protocol | Lymphoma | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.318, Cyclophosphamide monograph spanning p.318-321; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/animal) | Route | Source | As printed |
|---|---|---|---|
| 6.25–12.5 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.221 | • 6.25-12.5 mg/cat once daily 4 days/week. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Prodrug activated by hepatic CYP enzymes to form phosphoramide mustard, which alkylates DNA, cross-linking strands and inhibiting replication.
Sterile hemorrhagic cystitis from metabolite acrolein — concurrent furosemide/mesna and adequate hydration recommended. Myelosuppression. Handler precautions. Also used for immune-mediated diseases.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Cyclophosphamide dose range in cats, with cited source references: PO 200–300 mg/m2 q21d. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Cyclophosphamide in cats: PO.
Cited course lengths for Cyclophosphamide in cats include: Per protocol. Duration depends on the indication — match it to the specific dose rule in the table above.
Cyclophosphamide is indicated in cats for: Lymphoma.
These are general warnings for Cyclophosphamide across species; consult the cat dosing table above for species-specific guidance. Sterile hemorrhagic cystitis from metabolite acrolein — concurrent furosemide/mesna and adequate hydration recommended. Myelosuppression. Handler precautions. Also used for immune-mediated diseases.
Why a species-specific page? Cyclophosphamide pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.