Cat · Felis catus · typical adult weight 2.50–7.00 kg
Cyclophosphamide is dosed at 200–300 mg/m2 PO q21d in cats, per Plumb's Veterinary Drug Handbook, 9th Ed. Cyclophosphamide is used in cats for Lymphoma. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Cyclophosphamide in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Cytoxan
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 200–300 mg/m2 | q21d | Per protocol | Lymphoma | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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Prodrug activated by hepatic CYP enzymes to form phosphoramide mustard, which alkylates DNA, cross-linking strands and inhibiting replication.
Sterile hemorrhagic cystitis from metabolite acrolein — concurrent furosemide/mesna and adequate hydration recommended. Myelosuppression. Handler precautions. Also used for immune-mediated diseases.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Cyclophosphamide dose range in cats, with cited source references: PO 200–300 mg/m2 q21d. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Cyclophosphamide in cats: PO.
Cited course lengths for Cyclophosphamide in cats include: Per protocol. Duration depends on the indication — match it to the specific dose rule in the table above.
Cyclophosphamide is indicated in cats for: Lymphoma.
These are general warnings for Cyclophosphamide across species; consult the cat dosing table above for species-specific guidance. Sterile hemorrhagic cystitis from metabolite acrolein — concurrent furosemide/mesna and adequate hydration recommended. Myelosuppression. Handler precautions. Also used for immune-mediated diseases.
Why a species-specific page? Cyclophosphamide pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.