Cat · Felis catus · typical adult weight 2.50–7.00 kg
Chlorambucil is dosed at 2 mg per cat PO q48-72h in cats, per Kiselow MA, Rassnick KM, McDonough SP, et al. Outcome of cats with low-grade lymphocytic lymphoma: 41 cases (1995-2005). Javma-Journal of the American Veterinary Medical Association. 2008;232(3):405-410. doi:10.2460/javma.232.3.405 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.271 (2026-08-01).. Chlorambucil is used in cats for Small cell lymphoma, IBD (severe). Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Chlorambucil in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Leukeran
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2 mg per cat | q48-72h | Long-term | Small cell lymphoma, IBD (severe) | Strong | Kiselow MA, Rassnick KM, McDonough SP, et al. Outcome of cats with low-grade lymphocytic lymphoma: 41 cases (1995-2005). Javma-Journal of the American Veterinary Medical Association. 2008;232(3):405-410. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.271 (2026-08-01). |
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Alkylates DNA, forming cross-links that inhibit DNA replication and transcription. Slow-acting with relatively mild myelosuppression.
Cytotoxic — handler precautions required (gloves). Myelosuppression (monitor CBC q2 weeks initially). Commonly used for feline small cell lymphoma and IBD. Well-tolerated in cats.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Chlorambucil dose range in cats, with cited source references: PO 2 mg per cat q48-72h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Chlorambucil in cats: PO.
Cited course lengths for Chlorambucil in cats include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Chlorambucil is indicated in cats for: Small cell lymphoma, IBD (severe).
These are general warnings for Chlorambucil across species; consult the cat dosing table above for species-specific guidance. Cytotoxic — handler precautions required (gloves). Myelosuppression (monitor CBC q2 weeks initially). Commonly used for feline small cell lymphoma and IBD. Well-tolerated in cats.
Why a species-specific page? Chlorambucil pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.