Cat · Felis catus · typical adult weight 2.50–7.00 kg
Chlorambucil is dosed at 2 mg per cat PO q48-72h in cats, per Kiselow MA, Rassnick KM, McDonough SP, et al. Outcome of cats with low-grade lymphocytic lymphoma: 41 cases (1995-2005). Javma-Journal of the American Veterinary Medical Association. 2008;232(3):405-410. doi:10.2460/javma.232.3.405 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.271 (2026-08-01). — Plumb's 10th ed (held) printed p.244, Chlorambucil monograph spanning p.243-244; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Chlorambucil is used in cats for Small cell lymphoma, IBD (severe). Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Chlorambucil in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Leukeran
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2 mg per cat | q48-72h | Long-term | Small cell lymphoma, IBD (severe) | Strong | Kiselow MA, Rassnick KM, McDonough SP, et al. Outcome of cats with low-grade lymphocytic lymphoma: 41 cases (1995-2005). Javma-Journal of the American Veterinary Medical Association. 2008;232(3):405-410. doi:10.2460/javma.232.3.405 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.271 (2026-08-01). — Plumb's 10th ed (held) printed p.244, Chlorambucil monograph spanning p.243-244; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 1.4 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.92 | stitute for cyclophosphamide in the CHOP protocol: 1.4 mg/kg p.o. once. • Feline pemphigus foliaceus or severe feline eosinophilic granulom |
| 0.1–0.2 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.92 | granuloma complex (in combination with corticosteroids): 0.1-0.2 mg/kg p.o. q24h until marked improvement of clinical signs; then alternate-day dosing, |
| 0.1–0.2 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.176 | • Immune-mediated disease: 0.1-0.2 mg/kg (approximately one-half tablet) q24h |
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Alkylates DNA, forming cross-links that inhibit DNA replication and transcription. Slow-acting with relatively mild myelosuppression.
Cytotoxic — handler precautions required (gloves). Myelosuppression (monitor CBC q2 weeks initially). Commonly used for feline small cell lymphoma and IBD. Well-tolerated in cats.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Chlorambucil dose range in cats, with cited source references: PO 2 mg per cat q48-72h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Chlorambucil in cats: PO.
Cited course lengths for Chlorambucil in cats include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Chlorambucil is indicated in cats for: Small cell lymphoma, IBD (severe).
These are general warnings for Chlorambucil across species; consult the cat dosing table above for species-specific guidance. Cytotoxic — handler precautions required (gloves). Myelosuppression (monitor CBC q2 weeks initially). Commonly used for feline small cell lymphoma and IBD. Well-tolerated in cats.
Why a species-specific page? Chlorambucil pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.