ExoticRx · exoticrx.com/drugs/cyclophosphamide
US brand names:Cytoxan
Cyclophosphamide is dosed at 200–300 mg/m2 PO q21d or 50 mg/m2 daily x4 days/week in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Prodrug activated by hepatic CYP enzymes to form phosphoramide mustard, which alkylates DNA, cross-linking strands and inhibiting replication.
Sterile hemorrhagic cystitis from metabolite acrolein — concurrent furosemide/mesna and adequate hydration recommended. Myelosuppression. Handler precautions. Also used for immune-mediated diseases.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.