Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Mitoxantrone is dosed at 5–6 mg/m2 IV q21 days in dogs, per Marquardt TM, Lindley SES, Smith AN, et al. Substitution of mitoxantrone for doxorubicin in a multidrug chemotherapeutic protocol for first-line treatment of dogs with multicentric intermediate- to large-cell lymphoma. J Am Vet Med Assoc. 2019;254(2):236-242. doi:10.2460/javma.254.2.236 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.930 (2026-08-01).. Mitoxantrone is used in dogs for Lymphoma, carcinomas. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Mitoxantrone in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Novantrone
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 5–6 mg/m2 | q21 days | 4-6 cycles | Lymphoma, carcinomas | Moderate | Marquardt TM, Lindley SES, Smith AN, et al. Substitution of mitoxantrone for doxorubicin in a multidrug chemotherapeutic protocol for first-line treatment of dogs with multicentric intermediate- to large-cell lymphoma. J Am Vet Med Assoc. 2019;254(2):236-242. doi:10.2460/javma.254.2.236 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.930 (2026-08-01). |
Need the exact dose for your patient?
Enter your dog's weight to check these cited ranges in the calculator — unit and concentration math done for you.
Intercalates DNA and inhibits topoisomerase II. Related to anthracyclines but less cardiotoxic. Also disrupts RNA synthesis.
Less cardiotoxic than doxorubicin — used as alternative. Myelosuppression dose-limiting. Blue-green discoloration of urine/sclera. Safe in cats (unlike cisplatin).
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Mitoxantrone dose range in dogs, with cited source references: IV 5–6 mg/m2 q21 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Mitoxantrone in dogs: IV.
Cited course lengths for Mitoxantrone in dogs include: 4-6 cycles. Duration depends on the indication — match it to the specific dose rule in the table above.
Mitoxantrone is indicated in dogs for: Lymphoma, carcinomas.
These are general warnings for Mitoxantrone across species; consult the dog dosing table above for species-specific guidance. Less cardiotoxic than doxorubicin — used as alternative. Myelosuppression dose-limiting. Blue-green discoloration of urine/sclera. Safe in cats (unlike cisplatin).
Why a species-specific page? Mitoxantrone pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.