ExoticRx · exoticrx.com/drugs/mitoxantrone
US brand names:Novantrone
Mitoxantrone is dosed at 6–6.5 mg/m2 IV q21 days in cats, per Cunha SCS, Corgozinho KB, Souza HJM, Silva K, Ferreira AMR. Adjuvant chemotherapy with mitoxantrone for cats with mammary carcinomas treated with radical mastectomy. J Feline Med Surg. 2015;17(12):1000-1004. doi:10.1177/1098612x14567159 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.930 (2026-08-01).. Verify against current literature before clinical use.
Intercalates DNA and inhibits topoisomerase II. Related to anthracyclines but less cardiotoxic. Also disrupts RNA synthesis.
Less cardiotoxic than doxorubicin — used as alternative. Myelosuppression dose-limiting. Blue-green discoloration of urine/sclera. Safe in cats (unlike cisplatin).
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | IV | 6–6.5 mg/m2 | q21 days | Moderate | Cunha SCS, Corgozinho KB, Souza HJM, Silva K, Ferreira AMR. Adjuvant chemotherapy with mitoxantrone for cats with mammary carcinomas treated with radical mastectomy. J Feline Med Surg. 2015;17(12):1000-1004. doi:10.1177/1098612x14567159 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.930 (2026-08-01). |
| Dog (Domestic) | IV | 5–6 mg/m2 | q21 days | Moderate | Marquardt TM, Lindley SES, Smith AN, et al. Substitution of mitoxantrone for doxorubicin in a multidrug chemotherapeutic protocol for first-line treatment of dogs with multicentric intermediate- to large-cell lymphoma. J Am Vet Med Assoc. 2019;254(2):236-242. doi:10.2460/javma.254.2.236 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.930 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.