Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Ciprofloxacin is dosed at 25 mg/kg PO q24h in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023), Ciprofloxacin, p.295, DOGS row; superscript 1 = Papich MG. Ciprofloxacin pharmacokinetics in clinical canine patients. J Vet Intern Med. 2017;31(5):1508-1513. Corroborated by Papich, Saunders Handbook of Veterinary Drugs 4th ed p.189 ('Dogs • 25 mg/kg q24h PO') and Riviere & Papich, Veterinary Pharmacology and Therapeutics 10th ed p.983 ('Ciprofloxacin | 25 (oral) | recommended daily dose 25-30 once daily | Papich, 2012') — Plumb's 10th ed (held) printed p.268, Ciprofloxacin monograph spanning p.265-268; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855; Veterinary Pharmacology and Therapeutics — ISBN 9781118855829, https://openlibrary.org/isbn/9781118855829. Ciprofloxacin is used in dogs for Gram-negative infections, UTI. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Ciprofloxacin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Cipro, Baytril
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 25 mg/kg | q24h | 7-14 days | Gram-negative infections, UTI | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023), Ciprofloxacin, p.295, DOGS row; superscript 1 = Papich MG. Ciprofloxacin pharmacokinetics in clinical canine patients. J Vet Intern Med. 2017;31(5):1508-1513. Corroborated by Papich, Saunders Handbook of Veterinary Drugs 4th ed p.189 ('Dogs • 25 mg/kg q24h PO') and Riviere & Papich, Veterinary Pharmacology and Therapeutics 10th ed p.983 ('Ciprofloxacin | 25 (oral) | recommended daily dose 25-30 once daily | Papich, 2012') — Plumb's 10th ed (held) printed p.268, Ciprofloxacin monograph spanning p.265-268; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855; Veterinary Pharmacology and Therapeutics — ISBN 9781118855829, https://openlibrary.org/isbn/9781118855829 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 25 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.189 | • 25 mg/kg q24h PO. • 20 mg/kg q24h, PO. |
| 20 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.189 | • 25 mg/kg q24h PO. • 20 mg/kg q24h, PO. |
| 15 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.189 | • 15 mg/kg q24h IV. • 10 mg/kg q24h IV. |
| 10 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.189 | • 15 mg/kg q24h IV. • 10 mg/kg q24h IV. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication. Active metabolite of enrofloxacin in some species. Concentration-dependent killing.
Avoid in young growing animals (cartilage damage). May cause CNS stimulation. Drug interactions with antacids, sucralfate. Cats: retinal degeneration risk at high doses.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Ciprofloxacin dose range in dogs, with cited source references: PO 25 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Ciprofloxacin in dogs: PO.
Cited course lengths for Ciprofloxacin in dogs include: 7-14 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Ciprofloxacin is indicated in dogs for: Gram-negative infections, UTI.
These are general warnings for Ciprofloxacin across species; consult the dog dosing table above for species-specific guidance. Avoid in young growing animals (cartilage damage). May cause CNS stimulation. Drug interactions with antacids, sucralfate. Cats: retinal degeneration risk at high doses.
Why a species-specific page? Ciprofloxacin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.