ExoticRx · exoticrx.com/drugs/cladribine
US brand names:Leustatin
Adenosine deaminase-resistant purine nucleoside analogue. Phosphorylated intracellularly to active triphosphate form that incorporates into DNA, causing strand breaks and apoptosis.
Profound lymphopenia — immunosuppression lasting months. Myelosuppression. Fever common. Used investigationally for lymphocytic leukemia and low-grade lymphoma in dogs.
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