ExoticRx · exoticrx.com/drugs/cladribine
US brand names:Leustatin
Cladribine is dosed at 0.1–0.14 mg/kg SC 0.1-0.14mg/kg SC q24h x 5 days per cycle in dogs, per Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed. Verify against current literature before clinical use.
Adenosine deaminase-resistant purine nucleoside analogue. Phosphorylated intracellularly to active triphosphate form that incorporates into DNA, causing strand breaks and apoptosis.
Profound lymphopenia — immunosuppression lasting months. Myelosuppression. Fever common. Used investigationally for lymphocytic leukemia and low-grade lymphoma in dogs.
Species references:All Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Cladribine CRI dose rule from the ExoticRx formulary. Verify against current literature before clinical use; CRI rates differ from bolus dosing and route, dilution, and monitoring matter. Sign in for the complete per-species CRI protocol set.
| Species | Route | Rate | Indication | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.1–0.14 mg/kgIV CRI over 2h q24h x 5 days per cycle | Low-grade lymphocytic lymphoma / CLL | Weak | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
Low-grade lymphocytic lymphoma / CLL
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.1–0.14 mg/kg | IV CRI over 2h q24h x 5 days per cycle | Weak | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
| Dog (Domestic) | SC | 0.1–0.14 mg/kg | 0.1-0.14mg/kg SC q24h x 5 days per cycle | Weak | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.