ExoticRx · exoticrx.com/drugs/dactinomycin
Cosmegen
Intercalates into DNA between guanine-cytosine base pairs, blocking RNA polymerase and inhibiting transcription. Also causes topoisomerase II-mediated DNA breaks.
Severe vesicant — extravasation causes tissue necrosis. Potent myelosuppression and GI toxicity. Radiosensitizer — avoid concurrent radiation. Very limited veterinary use.
Species references:All Dog (Domestic) drugs
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