ExoticRx · exoticrx.com/drugs/dexrazoxane
US brand names:Zinecard
Intracellularly hydrolyzed to open-ring form that chelates iron, preventing iron-mediated free radical generation responsible for doxorubicin cardiotoxicity.
Administered 15-30 minutes before doxorubicin. 10:1 ratio (dexrazoxane:doxorubicin). May slightly increase myelosuppression. Used to extend cumulative doxorubicin dose limits.
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.