ExoticRx · exoticrx.com/drugs/diethylstilbestrol
US brand names:DES(compounded)
Diethylstilbestrol is dosed at 0.1–1 mg per dog PO q24h x 5 days, then q3-7 days in dogs, per Byron JK. Micturition Disorders. Vet Clin North Am Small Animal Pract. 2015;45(4):769-782. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.419 (2026-08-01).. Verify against current literature before clinical use.
Synthetic non-steroidal estrogen that increases urethral sphincter tone and sensitivity to alpha-adrenergic stimulation. Treats hormone-responsive incontinence.
Aplastic anemia risk with high or prolonged doses. Use lowest effective dose. Loading then maintenance dosing. Monitor CBC. Feminizing effects in males.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.1–1 mg per dog | q24h x 5 days, then q3-7 days | Moderate | Byron JK. Micturition Disorders. Vet Clin North Am Small Animal Pract. 2015;45(4):769-782. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.419 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.