Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Diethylstilbestrol is dosed at 0.1–1 mg per dog PO q24h x 5 days, then q3-7 days in dogs, per Byron JK. Micturition Disorders. Vet Clin North Am Small Animal Pract. 2015;45(4):769-782. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.419 (2026-08-01).. Diethylstilbestrol is used in dogs for Hormone-responsive urinary incontinence. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Diethylstilbestrol in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: DES
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.1–1 mg per dog | q24h x 5 days, then q3-7 days | Long-term maintenance | Hormone-responsive urinary incontinence | Moderate | Byron JK. Micturition Disorders. Vet Clin North Am Small Animal Pract. 2015;45(4):769-782. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.419 (2026-08-01). |
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Enter your dog's weight to check these cited ranges in the calculator — unit and concentration math done for you.
Synthetic non-steroidal estrogen that increases urethral sphincter tone and sensitivity to alpha-adrenergic stimulation. Treats hormone-responsive incontinence.
Aplastic anemia risk with high or prolonged doses. Use lowest effective dose. Loading then maintenance dosing. Monitor CBC. Feminizing effects in males.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Diethylstilbestrol dose range in dogs, with cited source references: PO 0.1–1 mg per dog q24h x 5 days, then q3-7 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Diethylstilbestrol in dogs: PO.
Cited course lengths for Diethylstilbestrol in dogs include: Long-term maintenance. Duration depends on the indication — match it to the specific dose rule in the table above.
Diethylstilbestrol is indicated in dogs for: Hormone-responsive urinary incontinence.
These are general warnings for Diethylstilbestrol across species; consult the dog dosing table above for species-specific guidance. Aplastic anemia risk with high or prolonged doses. Use lowest effective dose. Loading then maintenance dosing. Monitor CBC. Feminizing effects in males.
Why a species-specific page? Diethylstilbestrol pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.