Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Hydrochlorothiazide-Amiloride is dosed at 1–2 mg/kg PO q12h in dogs, per Atkins CE and Häggström J (2012) Pharmacologic management of myxomatous mitral valve disease in dogs. Journal of Veterinary Cardiology 14, 165-184 — Verified against BSAVA Small Animal Formulary, 10th Ed, Part A, p.212 (2026-08-01).. Hydrochlorothiazide-Amiloride is used in dogs for Calcium oxalate stone prevention. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Hydrochlorothiazide-Amiloride in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Moduretic
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–2 mg/kg | q12h | Long-term maintenance; monitor calcium and electrolytes | Calcium oxalate stone prevention | Moderate | Atkins CE and Häggström J (2012) Pharmacologic management of myxomatous mitral valve disease in dogs. Journal of Veterinary Cardiology 14, 165-184 — Verified against BSAVA Small Animal Formulary, 10th Ed, Part A, p.212 (2026-08-01). |
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Hydrochlorothiazide inhibits sodium reabsorption in the distal tubule while amiloride blocks epithelial sodium channels, providing potassium-sparing diuresis.
Monitor electrolytes, especially potassium. Contraindicated with hyperkalemia. May reduce calcium excretion (useful for calcium oxalate stone prevention).
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Hydrochlorothiazide-Amiloride dose range in dogs, with cited source references: PO 1–2 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Hydrochlorothiazide-Amiloride in dogs: PO.
Cited course lengths for Hydrochlorothiazide-Amiloride in dogs include: Long-term maintenance; monitor calcium and electrolytes. Duration depends on the indication — match it to the specific dose rule in the table above.
Hydrochlorothiazide-Amiloride is indicated in dogs for: Calcium oxalate stone prevention.
These are general warnings for Hydrochlorothiazide-Amiloride across species; consult the dog dosing table above for species-specific guidance. Monitor electrolytes, especially potassium. Contraindicated with hyperkalemia. May reduce calcium excretion (useful for calcium oxalate stone prevention).
Why a species-specific page? Hydrochlorothiazide-Amiloride pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.