Mannitol for Dogs

Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg

Mannitol is dosed at 0.5–2 g/kg IV q4-6h (max 3 doses in 24h) in dogs, per BSAVA Small Animal Formulary, 10th Ed, Part A, Mannitol, p.242 (corpus PDF p.258); corroborated by Papich, Saunders Handbook of Veterinary Drugs, Mannitol, p.471 (corpus PDF p.499) — SOURCE EDITION: BSAVA Small Animal Formulary, Part A — Canine and Feline — ISBN 9781910443705, https://openlibrary.org/isbn/9781910443705; Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855. Mannitol is used in dogs for Cerebral edema, acute glaucoma, oliguric renal failure. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Mannitol in dogs, drawn from published veterinary references. Verify against current literature before clinical use.

US trade names: Osmitrol

Dose ranges

Route	Dose	Frequency	Duration	Indication	Evidence	Source
IV	0.5–2 g/kg	q4-6h (max 3 doses in 24h)	Short-term (24-48h)	Cerebral edema, acute glaucoma, oliguric renal failure

What each reference text prints

Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.

The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.

Printed doses in % for this drug and species, by source
Dose (%)	Route	Source	As printed
25	—	Papich Saunders Handbook of Veterinary Drugs, 4th edp.499	• Glaucoma or central nervous system (CNS) edema: 0.25-2 g/kg of 15%-25%
15	—	Papich Saunders Handbook of Veterinary Drugs, 4th edp.499	• Glaucoma or central nervous system (CNS) edema: 0.25-2 g/kg of 15%-25%
25	IV	Papich Saunders Handbook of Veterinary Drugs, 4th edp.499	• Diuretic: 1 g/kg of 5%-25% solution IV to maintain urine flow.
5	IV

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Side effects & warnings

Used for cerebral edema, acute glaucoma, and oliguric renal failure. Administer through filter (may crystallize). May cause volume overload initially. CONTRAINDICATED in pulmonary edema, dehydration, anuria.

Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.

Frequently asked questions

What is the dose of Mannitol for Dogs?

Mannitol dose range in dogs, with cited source references: IV 0.5–2 g/kg q4-6h (max 3 doses in 24h). Reference ranges from cited sources — verify against current literature before clinical use.

How is Mannitol administered in Dogs?

Documented routes for Mannitol in dogs: IV.

How long is Mannitol given in Dogs?

Cited course lengths for Mannitol in dogs include: Short-term (24-48h). Duration depends on the indication — match it to the specific dose rule in the table above.

What conditions does Mannitol treat in Dogs?

Mannitol is indicated in dogs for: Cerebral edema, acute glaucoma, oliguric renal failure.

What are the side effects of Mannitol in Dogs?

These are general warnings for Mannitol across species; consult the dog dosing table above for species-specific guidance. Used for cerebral edema, acute glaucoma, and oliguric renal failure. Administer through filter (may crystallize). May cause volume overload initially. CONTRAINDICATED in pulmonary edema, dehydration, anuria.

Why a species-specific page? Mannitol pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.

Printed doses in g/kg for this drug and species, by source
Dose (g/kg)	Route	Source	As printed
0.25–2	IV	BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.258	0.25-2 g/kg i.v. infusion of 15-20% solution. There is some evidence that higher doses have greater
0.25–1	IV	BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.258	ffect, but lower doses allow for repeated boluses. Doses of 0.25-1.0 g/kg are recommended. The dose is given over 20-30 min. The dose may be repeated on
0.5–2	IV	BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.258	• Acute glaucoma (if refractory to topical treatments): 0.5-2 g/kg i.v. infusion over 30 min. Withholding water for the first few hours after adm
0.25–0.5	IV	BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.258	failure (as an alternative to using furosemide): 0.25-0.5 g/kg i.v. infusion over 5-10 min. If successful can repeat in 4 hours. Rehydrate the patient p

Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.