Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Allopurinol is dosed at 10–15 mg/kg PO q12h in dogs, per Denerolle P, Bourdoiseau G. Combination allopurinol and antimony treatment versus antimony alone and allopurinol alone in the treatment of canine leishmaniasis (96 cases). J Vet Intern Med. 1999;13(5):413-415. doi:10.1111/j.1939-1676.1999.tb01455.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.65 (2026-08-01). — Plumb's 10th ed (held) printed p.37, Allopurinol monograph spanning p.37-38; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Allopurinol is used in dogs for Urate urolithiasis prevention. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Allopurinol in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Zyloprim, Aloprim
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 10–15 mg/kg | q12h | Long-term maintenance; monitor uric acid levels and for xanthine stones |
| Urate urolithiasis prevention |
| Strong |
| Denerolle P, Bourdoiseau G. Combination allopurinol and antimony treatment versus antimony alone and allopurinol alone in the treatment of canine leishmaniasis (96 cases). J Vet Intern Med. 1999;13(5):413-415. doi:10.1111/j.1939-1676.1999.tb01455.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.65 (2026-08-01). — Plumb's 10th ed (held) printed p.37, Allopurinol monograph spanning p.37-38; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 10 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.28 | ■ Dissolution: 10 mg/kg p.o. q8h or 15 mg/kg p.o. q12h for up to 4 weeks. ■ Prevention: 10-15 mg/kg p |
| 15 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.28 | ■ Dissolution: 10 mg/kg p.o. q8h or 15 mg/kg p.o. q12h for up to 4 weeks. ■ Prevention: 10-15 mg/kg p.o. q24h. |
| 10–15 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.28 | g/kg p.o. q12h for up to 4 weeks. ■ Prevention: 10-15 mg/kg p.o. q24h. |
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Inhibits xanthine oxidase, reducing conversion of hypoxanthine to xanthine and xanthine to uric acid. Lowers serum and urinary urate levels.
May cause xanthine urolithiasis if protein intake not controlled. Feed low-purine diet concurrently. Monitor uric acid levels and hepatic function.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Allopurinol dose range in dogs, with cited source references: PO 10–15 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Allopurinol in dogs: PO.
Cited course lengths for Allopurinol in dogs include: Long-term maintenance; monitor uric acid levels and for xanthine stones. Duration depends on the indication — match it to the specific dose rule in the table above.
Allopurinol is indicated in dogs for: Urate urolithiasis prevention.
These are general warnings for Allopurinol across species; consult the dog dosing table above for species-specific guidance. May cause xanthine urolithiasis if protein intake not controlled. Feed low-purine diet concurrently. Monitor uric acid levels and hepatic function.
Why a species-specific page? Allopurinol pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 10 |
| PO |
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.47 |
| • Leishmaniasis: 10 mg/kg q12h PO for at least 4 months and as long as 6 months. |
| 15 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.47 | For leishmaniasis, some clinicians have used 15 mg/kg q12h, and then if there is |
| 7–10 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.47 | a response, administer 7-10 mg/kg q12-24h PO. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.