Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Allopurinol is dosed at 10–15 mg/kg PO q12h in dogs, per Denerolle P, Bourdoiseau G. Combination allopurinol and antimony treatment versus antimony alone and allopurinol alone in the treatment of canine leishmaniasis (96 cases). J Vet Intern Med. 1999;13(5):413-415. doi:10.1111/j.1939-1676.1999.tb01455.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.65 (2026-08-01).. Allopurinol is used in dogs for Urate urolithiasis prevention. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Allopurinol in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Zyloprim, Aloprim
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 10–15 mg/kg | q12h | Long-term maintenance; monitor uric acid levels and for xanthine stones | Urate urolithiasis prevention | Strong | Denerolle P, Bourdoiseau G. Combination allopurinol and antimony treatment versus antimony alone and allopurinol alone in the treatment of canine leishmaniasis (96 cases). J Vet Intern Med. 1999;13(5):413-415. doi:10.1111/j.1939-1676.1999.tb01455.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.65 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits xanthine oxidase, reducing conversion of hypoxanthine to xanthine and xanthine to uric acid. Lowers serum and urinary urate levels.
May cause xanthine urolithiasis if protein intake not controlled. Feed low-purine diet concurrently. Monitor uric acid levels and hepatic function.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Allopurinol dose range in dogs, with cited source references: PO 10–15 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Allopurinol in dogs: PO.
Cited course lengths for Allopurinol in dogs include: Long-term maintenance; monitor uric acid levels and for xanthine stones. Duration depends on the indication — match it to the specific dose rule in the table above.
Allopurinol is indicated in dogs for: Urate urolithiasis prevention.
These are general warnings for Allopurinol across species; consult the dog dosing table above for species-specific guidance. May cause xanthine urolithiasis if protein intake not controlled. Feed low-purine diet concurrently. Monitor uric acid levels and hepatic function.
Why a species-specific page? Allopurinol pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.