Allopurinol for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Allopurinol is used in dog for Urate urolithiasis prevention. Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Allopurinol in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Zyloprim, Aloprim
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 10–15 mg/kg | q12h | Long-term maintenance; monitor uric acid levels and for xanthine stones | Urate urolithiasis prevention | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Inhibits xanthine oxidase, reducing conversion of hypoxanthine to xanthine and xanthine to uric acid. Lowers serum and urinary urate levels.
Side effects & warnings
May cause xanthine urolithiasis if protein intake not controlled. Feed low-purine diet concurrently. Monitor uric acid levels and hepatic function.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Urinary drugs with dog dosing
Allopurinol dosing in other species
Why a species-specific page? Allopurinol pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.