Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Tiopronin is dosed at 15–20 mg/kg PO q12h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed - Tiopronin, Dosages, corpus p.1273. Tiopronin is used in dogs for Cystine urolithiasis prevention. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Tiopronin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Thiola
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 15–20 mg/kg | q12h | Long-term | Cystine urolithiasis prevention | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed - Tiopronin, Dosages, corpus p.1273 |
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Thiol compound that forms disulfide bond with cysteine producing a more soluble mixed disulfide compound. Reduces cystine stone formation.
Used for cystine urolithiasis prevention. GI upset, proteinuria. Monitor CBC and urinalysis. Better tolerated than D-penicillamine for cystinuria.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Tiopronin dose range in dogs, with cited source references: PO 15–20 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Tiopronin in dogs: PO.
Cited course lengths for Tiopronin in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Tiopronin is indicated in dogs for: Cystine urolithiasis prevention.
These are general warnings for Tiopronin across species; consult the dog dosing table above for species-specific guidance. Used for cystine urolithiasis prevention. GI upset, proteinuria. Monitor CBC and urinalysis. Better tolerated than D-penicillamine for cystinuria.
Why a species-specific page? Tiopronin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.