ExoticRx · exoticrx.com/drugs/tiopronin
US brand names:Thiola
Tiopronin is dosed at 15–20 mg/kg PO q12h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed - Tiopronin, Dosages, corpus p.1273. Verify against current literature before clinical use.
Thiol compound that forms disulfide bond with cysteine producing a more soluble mixed disulfide compound. Reduces cystine stone formation.
Used for cystine urolithiasis prevention. GI upset, proteinuria. Monitor CBC and urinalysis. Better tolerated than D-penicillamine for cystinuria.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 15–20 mg/kg | q12h | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed - Tiopronin, Dosages, corpus p.1273 |
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