ExoticRx · exoticrx.com/drugs/hydrochlorothiazide-amiloride
US brand names:Moduretic
Hydrochlorothiazide-Amiloride is dosed at 1–2 mg/kg PO q12h in dogs, per Atkins CE and Häggström J (2012) Pharmacologic management of myxomatous mitral valve disease in dogs. Journal of Veterinary Cardiology 14, 165-184 — Verified against BSAVA Small Animal Formulary, 10th Ed, Part A, p.212 (2026-08-01).. Verify against current literature before clinical use.
Hydrochlorothiazide inhibits sodium reabsorption in the distal tubule while amiloride blocks epithelial sodium channels, providing potassium-sparing diuresis.
Monitor electrolytes, especially potassium. Contraindicated with hyperkalemia. May reduce calcium excretion (useful for calcium oxalate stone prevention).
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 1–2 mg/kg | q12h | Moderate | Atkins CE and Häggström J (2012) Pharmacologic management of myxomatous mitral valve disease in dogs. Journal of Veterinary Cardiology 14, 165-184 — Verified against BSAVA Small Animal Formulary, 10th Ed, Part A, p.212 (2026-08-01). |
| Cat (Domestic) | PO | 1–2 mg/kg | q12-24h | Weak | Atkins CE and Häggström J (2012) Pharmacologic management of myxomatous mitral valve disease in dogs. Journal of Veterinary Cardiology 14, 165-184 — Verified against BSAVA Small Animal Formulary, 10th Ed, Part A, p.212 (2026-08-01). |
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