ExoticRx · exoticrx.com/drugs/docetaxel
Taxotere
Semi-synthetic taxane that promotes tubulin assembly and inhibits microtubule depolymerization. More potent than paclitaxel in vitro. Arrests cells in M phase.
Less hypersensitivity risk than paclitaxel (polysorbate 80 vehicle). Myelosuppression and peripheral neuropathy. Fluid retention with cumulative dosing. Premedicate with dexamethasone.
Species references:All Dog (Domestic) drugs
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