Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Enrofloxacin is dosed at 5–10 mg/kg IM q24h in dogs, per Papich, Saunders Handbook of Veterinary Drugs, 5th Ed, Enrofloxacin, Small Animal Dosage, Dogs - printed p.289 (corpus PDF p.317). Corroborating figures: BSAVA Small Animal Formulary 10th Ed, Enrofloxacin, printed p.148 - 'Dogs: 5 mg/kg s.c. q24h. Higher doses (10 mg/kg q24h) should be considered for certain sites, including prostatitis.'. Enrofloxacin is used in dogs for Bacterial infections when oral not feasible, Severe systemic infections, Bacterial infections (skin, UTI, respiratory), Complicated UTI, pyelonephritis. Routes documented in dogs: IM, IV, PO, SC. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 9 cited dose rules for Enrofloxacin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Baytril
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IM | 5–10 mg/kg | q24h | 5-10 days | Bacterial infections when oral not feasible | Strong | Papich, Saunders Handbook of Veterinary Drugs, 5th Ed, Enrofloxacin, Small Animal Dosage, Dogs - printed p.289 (corpus PDF p.317). Corroborating figures: BSAVA Small Animal Formulary 10th Ed, Enrofloxacin, printed p.148 - 'Dogs: 5 mg/kg s.c. q24h. Higher doses (10 mg/kg q24h) should be considered for certain sites, including prostatitis.' |
| IV | 5–10 mg/kg | q24h | Until oral feasible | Severe systemic infections | Strong | Papich, Saunders Handbook of Veterinary Drugs, 5th Ed, Enrofloxacin, Small Animal Dosage, Dogs - printed p.289 (corpus PDF p.317) |
| PO | 5–20 mg/kg | q24h | 7-14 days | Bacterial infections (skin, UTI, respiratory) | Strong | Baytril - Enrofloxacin Tablet, Coated [US Product Label for Dogs and Cats]. Elanco US Inc; 2020. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5012fe70-6394-45f5-be75-04297e39574d — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.480 (2026-08-01). |
| PO | 10–20 mg/kg | q24h | 14-28 days | Complicated UTI, pyelonephritis | Strong | Weese JS, Blondeau JM, Boothe D, et al. Antimicrobial use guidelines for treatment of urinary tract disease in dogs and cats: antimicrobial guidelines working group of the international society for companion animal infectious diseases. Vet Med Int. 2011;2011:263768. doi:10.4061/2011/263768 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.480 (2026-08-01). |
| PO | 10–20 mg/kg | q24h | 10-14 days minimum; extend if unresolved | Pneumonia (community-acquired) | Strong | Weese JS, Blondeau JM, Boothe D, et al. Antimicrobial use guidelines for treatment of urinary tract disease in dogs and cats: antimicrobial guidelines working group of the international society for companion animal infectious diseases. Vet Med Int. 2011;2011:263768. doi:10.4061/2011/263768 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.480 (2026-08-01). |
| PO | 10–20 mg/kg | q24h | 4-6 weeks minimum | Otitis media/interna | Moderate | Weese JS, Blondeau JM, Boothe D, et al. Antimicrobial use guidelines for treatment of urinary tract disease in dogs and cats: antimicrobial guidelines working group of the international society for companion animal infectious diseases. Vet Med Int. 2011;2011:263768. doi:10.4061/2011/263768 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.480 (2026-08-01). |
| PO | 10–20 mg/kg | q24h | 28-42 days | Prostatitis | Strong | Weese JS, Blondeau JM, Boothe D, et al. Antimicrobial use guidelines for treatment of urinary tract disease in dogs and cats: antimicrobial guidelines working group of the international society for companion animal infectious diseases. Vet Med Int. 2011;2011:263768. doi:10.4061/2011/263768 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.480 (2026-08-01). |
| PO | 10–20 mg/kg | q24h | 6-8 weeks minimum | Osteomyelitis | Moderate | Weese JS, Blondeau JM, Boothe D, et al. Antimicrobial use guidelines for treatment of urinary tract disease in dogs and cats: antimicrobial guidelines working group of the international society for companion animal infectious diseases. Vet Med Int. 2011;2011:263768. doi:10.4061/2011/263768 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.480 (2026-08-01). |
| SC | 5–10 mg/kg | q24h | 7-14 days | Bacterial infections when oral not feasible | Strong | BSAVA Small Animal Formulary, 10th edition, Part A - Canine and Feline; Enrofloxacin monograph, DOSES, printed p.148 (corpus PDF p.164). Secondary/contrast: Plumb's Veterinary Drug Handbook 9th ed, Enrofloxacin, printed p.453 (PDF p.480). |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription.
Avoid in growing animals (cartilage damage). Do NOT use in cats at doses >5mg/kg (retinal toxicity). Avoid concurrent use with theophylline.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Enrofloxacin dose ranges in dogs, with cited source references: IM 5–10 mg/kg q24h; IV 5–10 mg/kg q24h; PO 5–20 mg/kg q24h; PO 10–20 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Enrofloxacin in dogs: IM, IV, PO, SC.
Cited course lengths for Enrofloxacin in dogs include: 5-10 days; Until oral feasible; 7-14 days; 14-28 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Enrofloxacin is indicated in dogs for: Bacterial infections when oral not feasible, Severe systemic infections, Bacterial infections (skin, UTI, respiratory), Complicated UTI, pyelonephritis, Pneumonia (community-acquired), Otitis media/interna, Prostatitis, Osteomyelitis.
These are general warnings for Enrofloxacin across species; consult the dog dosing table above for species-specific guidance. Avoid in growing animals (cartilage damage). Do NOT use in cats at doses >5mg/kg (retinal toxicity). Avoid concurrent use with theophylline.
Why a species-specific page? Enrofloxacin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.