ExoticRx · exoticrx.com/drugs/etoposide
US brand names:VePesid, Toposar
Etoposide is dosed at 60–100 mg/m2 IV q21 days in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Inhibits topoisomerase II forming DNA-drug-enzyme complex causing double-strand DNA breaks. S and G2 phase specific.
Myelosuppression dose-limiting. Hypotension with rapid IV infusion (infuse over 30-60 min). Oral bioavailability variable. Used in some lymphoma rescue protocols.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 60–100 mg/m2 | q21 days | Weak | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.