ExoticRx · exoticrx.com/drugs/fosfomycin
US brand names:Monurol
Fosfomycin is dosed at 40–80 mg/kg PO (with food) q12h in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023), Fosfomycin, p.587, DOGS row; superscript 1 = Weese JS, Blondeau J, Boothe D, et al. ISCAID guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats. Vet J. 2019;247:8-25; superscript 14 = Harada K, Shimizu T, Kawaguchi K, Furuhashi T, Ishihara G. Urinary Pharmacokinetic and Pharmacodynamic Profiles of Fosfomycin against Extended-Spectrum β-Lactamase-Producing Escherichia coli with Canine Ex Vivo Modeling: A Pilot Study. Antibiotics. 2020;9(5):230. Verify against current literature before clinical use.
Inhibits MurA enzyme (enolpyruvyl transferase) in early cell wall synthesis. Unique mechanism with no cross-resistance to other classes.
Limited veterinary data. May cause GI upset. Useful for MDR urinary tract infections. Oral form has limited bioavailability except in urinary tract.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO (with food) | 40–80 mg/kg | q12h | Weak | Plumb's Veterinary Drug Handbook, 10th ed (2023), Fosfomycin, p.587, DOGS row; superscript 1 = Weese JS, Blondeau J, Boothe D, et al. ISCAID guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats. Vet J. 2019;247:8-25; superscript 14 = Harada K, Shimizu T, Kawaguchi K, Furuhashi T, Ishihara G. Urinary Pharmacokinetic and Pharmacodynamic Profiles of Fosfomycin against Extended-Spectrum β-Lactamase-Producing Escherichia coli with Canine Ex Vivo Modeling: A Pilot Study. Antibiotics. 2020;9(5):230 |
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