Grapiprant for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Grapiprant is used in dog for Osteoarthritis pain. Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Grapiprant in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Galliprant
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2 mg/kg | q24h | Long-term | Osteoarthritis pain | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Selectively blocks the EP4 prostaglandin receptor, the primary mediator of osteoarthritis pain and inflammation, without broadly inhibiting COX enzymes.
Side effects & warnings
Dogs only. Novel mechanism — does not broadly inhibit prostaglandin synthesis. Vomiting is most common adverse effect. Not for use with other NSAIDs.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Analgesic drugs with dog dosing
Why a species-specific page? Grapiprant pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.