Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Grapiprant is dosed at 2 mg/kg PO q24h in dogs, per GALLIPRANT - Grapiprant Tablet [US Product Label for Dogs]. Elanco US Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a38cc5c6-93e8-4c90-aabc-33bc8423beab — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.622 (2026-08-01).. Grapiprant is used in dogs for Osteoarthritis pain. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Grapiprant in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Galliprant
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2 mg/kg | q24h | Long-term | Osteoarthritis pain | Strong | GALLIPRANT - Grapiprant Tablet [US Product Label for Dogs]. Elanco US Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a38cc5c6-93e8-4c90-aabc-33bc8423beab — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.622 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Selectively blocks the EP4 prostaglandin receptor, the primary mediator of osteoarthritis pain and inflammation, without broadly inhibiting COX enzymes.
Dogs only. Novel mechanism — does not broadly inhibit prostaglandin synthesis. Vomiting is most common adverse effect. Not for use with other NSAIDs.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Grapiprant dose range in dogs, with cited source references: PO 2 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Grapiprant in dogs: PO.
Cited course lengths for Grapiprant in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Grapiprant is indicated in dogs for: Osteoarthritis pain.
These are general warnings for Grapiprant across species; consult the dog dosing table above for species-specific guidance. Dogs only. Novel mechanism — does not broadly inhibit prostaglandin synthesis. Vomiting is most common adverse effect. Not for use with other NSAIDs.
Why a species-specific page? Grapiprant pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.