Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Grapiprant is dosed at 2 mg/kg PO q24h in dogs, per GALLIPRANT - Grapiprant Tablet [US Product Label for Dogs]. Elanco US Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a38cc5c6-93e8-4c90-aabc-33bc8423beab — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.622 (2026-08-01). — Plumb's 10th ed (held) printed p.594, Grapiprant monograph spanning p.594-595; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Grapiprant is used in dogs for Osteoarthritis pain. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Grapiprant in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Galliprant
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2 mg/kg | q24h | Long-term | Osteoarthritis pain | Strong | GALLIPRANT - Grapiprant Tablet [US Product Label for Dogs]. Elanco US Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a38cc5c6-93e8-4c90-aabc-33bc8423beab — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.622 (2026-08-01). — Plumb's 10th ed (held) printed p.594, Grapiprant monograph spanning p.594-595; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 2 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.205 | 2 mg/kg once daily |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Selectively blocks the EP4 prostaglandin receptor, the primary mediator of osteoarthritis pain and inflammation, without broadly inhibiting COX enzymes.
Dogs only. Novel mechanism — does not broadly inhibit prostaglandin synthesis. Vomiting is most common adverse effect. Not for use with other NSAIDs.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Grapiprant dose range in dogs, with cited source references: PO 2 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Grapiprant in dogs: PO.
Cited course lengths for Grapiprant in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Grapiprant is indicated in dogs for: Osteoarthritis pain.
These are general warnings for Grapiprant across species; consult the dog dosing table above for species-specific guidance. Dogs only. Novel mechanism — does not broadly inhibit prostaglandin synthesis. Vomiting is most common adverse effect. Not for use with other NSAIDs.
Why a species-specific page? Grapiprant pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.