ExoticRx · exoticrx.com/drugs/grapiprant
US brand names:Galliprant
Grapiprant is dosed at 2 mg/kg PO q24h in dogs, per GALLIPRANT - Grapiprant Tablet [US Product Label for Dogs]. Elanco US Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a38cc5c6-93e8-4c90-aabc-33bc8423beab — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.622 (2026-08-01).. Verify against current literature before clinical use.
Selectively blocks the EP4 prostaglandin receptor, the primary mediator of osteoarthritis pain and inflammation, without broadly inhibiting COX enzymes.
Dogs only. Novel mechanism — does not broadly inhibit prostaglandin synthesis. Vomiting is most common adverse effect. Not for use with other NSAIDs.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 2 mg/kg | q24h | Strong | GALLIPRANT - Grapiprant Tablet [US Product Label for Dogs]. Elanco US Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a38cc5c6-93e8-4c90-aabc-33bc8423beab — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.622 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.